SNX21

SNX21
Identifiers
Aliases	SNX21, C20orf161, PP3993, SNX-L, dJ337O18.4, sorting nexin family member 21, SNXL
External IDs	MGI: 1917729; HomoloGene: 43132; GeneCards: SNX21; OMA:SNX21 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,843,276 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,635,736 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; right ovary; ; left ovary; ; skin of abdomen; ; right coronary artery; ; endothelial cell; ; right adrenal cortex; ; gastric mucosa; ; left adrenal cortex; ; left uterine tube;
	Top expressed in
	muscle of thigh; ; Rostral migratory stream; ; lip; ; lumbar spinal ganglion; ; superior frontal gyrus; ; primary visual cortex; ; facial motor nucleus; ; right kidney; ; cerebellar cortex; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipid binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding;
Cellular component	membrane; cytoplasmic vesicle; cytoplasmic vesicle membrane; endosome; early endosome membrane;
Biological process	protein transport;
	Sources:Amigo / QuickGO
Orthologs
	90203
	101113
	ENSG00000124104
	ENSMUSG00000050373
	Q969T3
	Q3UR97
	NM_001042632; NM_001042633; NM_033421; NM_152897
	NM_133924; NM_001399716
	NP_001036097; NP_001036098; NP_219489; NP_690857
	NP_598685; NP_001386645
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.^[5]^[6]^[7]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124104 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050373 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
^ Zeng W, Yuan W, Wang Y, Jiao W, Zhu Y, Huang C, Li D, Li Y, Zhu C, Wu X, Liu M (Dec 2002). "Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development". Biochem Biophys Res Commun. 299 (4): 542–8. doi:10.1016/S0006-291X(02)02695-5. PMID 12459172.
^ ^a ^b "Entrez Gene: SNX21 sorting nexin family member 21".

Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124104 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050373 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12461558-5] Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.

[pmid12459172-6] Zeng W, Yuan W, Wang Y, Jiao W, Zhu Y, Huang C, Li D, Li Y, Zhu C, Wu X, Liu M (Dec 2002). "Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development". Biochem Biophys Res Commun. 299 (4): 542–8. doi:10.1016/S0006-291X(02)02695-5. PMID 12459172.

[entrez-7] "Entrez Gene: SNX21 sorting nexin family member 21".

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v t e Sorting nexins
SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 SNX33
SNX-PX	SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29
SNX-Other	SNX13 SNX14 SNX15 SNX17 SNX19 SNX23 SNX25 SNX26 SNX27 SNX28 SNX31
Related articles	PX domain BAR domain Retromer

References

Further reading