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Protein-coding gene in the species Homo sapiens
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene .[ 5] [ 6]
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF , which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome . The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.[ 6]
SMARCE1 has been shown to interact with Estrogen receptor alpha ,[ 7] SMARCB1 [ 8] [ 9] SMARCA4 .[ 8] [ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000073584 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037935 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wang W, Chi T, Xue Y, Zhou S, Kuo A, Crabtree GR (Jan 1998). "Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes" . Proceedings of the National Academy of Sciences of the United States of America . 95 (2): 492–8. Bibcode :1998PNAS...95..492W . doi :10.1073/pnas.95.2.492 PMC 18447 PMID 9435219 . ^ a b "Entrez Gene: SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1" .^ Belandia B, Orford RL, Hurst HC, Parker MG (Aug 2002). "Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes" . The EMBO Journal . 21 (15): 4094–103. doi :10.1093/emboj/cdf412 . PMC 126156 PMID 12145209 . ^ a b Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (Oct 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex" . The EMBO Journal . 15 (19): 5370–82. doi :10.1002/j.1460-2075.1996.tb00921.x . PMC 452280 PMID 8895581 . ^ a b Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR (Nov 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling" . Cell . 95 (5): 625–36. doi :10.1016/S0092-8674(00)81633-5 PMID 9845365 . S2CID 3184211 .
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