SMAP1

SMAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRR
Identifiers
Aliases	SMAP1, SMAP-1, small ArfGAP 1
External IDs	OMIM: 611372; MGI: 2138261; HomoloGene: 134676; GeneCards: SMAP1; OMA:SMAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	70,862,011 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	23,961,398 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; oral cavity; ; pons; ; mucosa of pharynx; ; duodenum; ; skin of thigh; ; skin of hip; ; islet of Langerhans; ; ganglionic eminence;
	Top expressed in
	blood; ; genital tubercle; ; tail of embryo; ; seminiferous tubule; ; spermatid; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; superior frontal gyrus; ; calvaria; ; gastrula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin binding; metal ion binding; GTPase activator activity;
Cellular component	cytoplasm; plasma membrane; membrane;
Biological process	positive regulation of GTPase activity; regulation of clathrin-dependent endocytosis; positive regulation of erythrocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	60682
	98366
	ENSG00000112305
	ENSMUSG00000026155
	Q8IYB5
	Q91VZ6
	NM_001044305; NM_001281439; NM_001281440; NM_021940
	NM_001290683; NM_028534; NM_001357395
	NP_001037770; NP_001268368; NP_001268369; NP_068759
	NP_001277612; NP_082810; NP_001344324
	Wikidata
View/Edit Human	View/Edit Mouse

Stromal membrane-associated protein 1 is a protein that in humans is encoded by the SMAP1 gene.^[5]^[6]^[7]

The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112305 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026155 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sato Y, Hong HN, Yanai N, Obinata M (Sep 1998). "Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment". J Biochem. 124 (1): 209–16. doi:10.1093/oxfordjournals.jbchem.a022082. PMID 9644265.
^ Marcos I, Borrego S, Rodriguez de Cordoba S, Galan JJ, Antinolo G (Jul 2002). "Cloning, characterization and chromosome mapping of the human SMAP1 gene". Gene. 292 (1–2): 167–71. doi:10.1016/S0378-1119(02)00645-5. PMID 12119110.
^ ^a ^b "SMAP1 small ArfGAP 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-05-07.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tanabe K, Torii T, Natsume W, et al. (2005). "A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis". Mol. Biol. Cell. 16 (4): 1617–28. doi:10.1091/mbc.E04-08-0683. PMC 1073646. PMID 15659652.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Barragan I, Marcos I, Borrego S, Antiñolo G (2006). "Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa". Int. J. Mol. Med. 16 (6): 1163–7. doi:10.3892/ijmm.16.6.1163. PMID 16273301.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112305 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026155 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9644265-5] Sato Y, Hong HN, Yanai N, Obinata M (Sep 1998). "Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment". J Biochem. 124 (1): 209–16. doi:10.1093/oxfordjournals.jbchem.a022082. PMID 9644265.

[pmid12119110-6] Marcos I, Borrego S, Rodriguez de Cordoba S, Galan JJ, Antinolo G (Jul 2002). "Cloning, characterization and chromosome mapping of the human SMAP1 gene". Gene. 292 (1–2): 167–71. doi:10.1016/S0378-1119(02)00645-5. PMID 12119110.

[:0-7] "SMAP1 small ArfGAP 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-05-07.

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References

Further reading