SLFN5

SLFN5
Identifiers
Aliases	SLFN5, schlafen family member 5
External IDs	OMIM: 614952; MGI: 1329004; HomoloGene: 18839; GeneCards: SLFN5; OMA:SLFN5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	35,273,655 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	82,855,666 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; pancreatic ductal cell; ; superficial temporal artery; ; parietal pleura; ; pylorus; ; cardia; ; buccal mucosa cell; ; nasal epithelium; ; tendon of biceps brachii; ; nipple;
	Top expressed in
	muscle of thigh; ; white adipose tissue; ; right lung; ; myocardium of ventricle; ; esophagus; ; granulocyte; ; subcutaneous adipose tissue; ; soleus muscle; ; stroma of bone marrow; ; extraocular muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; nucleotide binding;
Cellular component	nucleus;
Biological process	cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	162394
	327978
	ENSG00000166750
	ENSMUSG00000054404
	Q08AF3
	Q8CBA2
	NM_144975; NM_001330183
	NM_183201
	NP_001317112; NP_659412
	NP_899024
	Wikidata
View/Edit Human	View/Edit Mouse

Schlafen family member 5 is a protein that in humans is encoded by the SLFN5 gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166750 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054404 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Schlafen family member 5". Retrieved 2020-04-11.

Katsoulidis E, Mavrommatis E, Woodard J, Shields MA, Sassano A, Carayol N, Sawicki KT, Munshi HG, Platanias LC (December 2010). "Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells". J. Biol. Chem. 285 (51): 40333–41. doi:10.1074/jbc.M110.151076. PMC 3001013. PMID 20956525.
Sassano A, Mavrommatis E, Arslan AD, Kroczynska B, Beauchamp EM, Khuon S, Chew TL, Green KJ, Munshi HG, Verma AK, Platanias LC (August 2015). "Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells". Mol. Cell. Biol. 35 (15): 2684–98. doi:10.1128/MCB.00019-15. PMC 4524119. PMID 26012550.
Companioni Nápoles O, Tsao AC, Sanz-Anquela JM, Sala N, Bonet C, Pardo ML, Ding L, Simo O, Saqui-Salces M, Blanco VP, Gonzalez CA, Merchant JL (January 2017). "SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer". J. Gastroenterol. 52 (1): 39–49. doi:10.1007/s00535-016-1202-4. PMC 5045746. PMID 27032393.
Arslan AD, Sassano A, Saleiro D, Lisowski P, Kosciuczuk EM, Fischietti M, Eckerdt F, Fish EN, Platanias LC (October 2017). "Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma". Oncogene. 36 (43): 6006–6019. doi:10.1038/onc.2017.205. PMC 5821504. PMID 28671669.

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