SLC8B1

SLC8B1
Identifiers
Aliases	SLC8B1, NCKX6, NCLX, SLC24A6, solute carrier family 8 member B1
External IDs	OMIM: 609841; MGI: 2180781; HomoloGene: 41602; GeneCards: SLC8B1; OMA:SLC8B1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	113,359,493 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	120,672,089 bp
RNA expression pattern
	Top expressed in
	left adrenal cortex; ; right adrenal gland; ; right adrenal cortex; ; left ovary; ; right ovary; ; spleen; ; mucosa of transverse colon; ; sural nerve; ; granulocyte; ; epithelium of colon;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; decidua; ; left lobe of liver; ; lip; ; tibiofemoral joint; ; yolk sac; ; left colon; ; gastrula; ; mesenteric lymph nodes;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; identical protein binding; antiporter activity; calcium:cation antiporter activity; calcium:sodium antiporter activity; calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential;
Cellular component	integral component of membrane; membrane; plasma membrane; mitochondrial crista; mitochondrion; integral component of mitochondrial membrane; sarcolemma; mitochondrial inner membrane;
Biological process	sodium ion transmembrane transport; regulation of cytosolic calcium ion concentration; glucose homeostasis; response to stimulus; regulation of insulin secretion; sodium ion transport; ion transport; calcium ion transmembrane transport; regulation of cardiac muscle cell membrane potential; calcium ion transport; transmembrane transport; mitochondrial calcium ion transmembrane transport; mitochondrial calcium ion homeostasis; calcium export from the mitochondrion; regulation of lymphocyte chemotaxis; regulation of store-operated calcium entry;
	Sources:Amigo / QuickGO
Orthologs
	80024
	170756
	ENSG00000089060
	ENSMUSG00000032754
	Q6J4K2
	Q925Q3
	NM_024959; NM_001330466; NM_001358345
	NM_001177594; NM_001177595; NM_133221
	NP_001317395; NP_079235; NP_001345274
	NP_001171065; NP_001171066; NP_573484
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 is a protein that in humans is encoded by the SLC8B1 gene.^[5]

Function

SLC24A6 belongs to a family of Potassium-dependent sodium-calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089060 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032754 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1".
^ Cai X, Lytton J (February 2004). "Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6". The Journal of Biological Chemistry. 279 (7): 5867–76. doi:10.1074/jbc.M310908200. PMID 14625281.

Boyman L, Williams GS, Khananshvili D, Sekler I, Lederer WJ (June 2013). "NCLX: the mitochondrial sodium calcium exchanger". Journal of Molecular and Cellular Cardiology. 59: 205–13. doi:10.1016/j.yjmcc.2013.03.012. PMC 3951392. PMID 23538132.
Palty R, Ohana E, Hershfinkel M, Volokita M, Elgazar V, Beharier O, Silverman WF, Argaman M, Sekler I (June 2004). "Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger". The Journal of Biological Chemistry. 279 (24): 25234–40. doi:10.1074/jbc.M401229200. PMID 15060069.
Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK (October 2013). "Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network". Nutrition, Metabolism, and Cardiovascular Diseases. 23 (10): 987–94. doi:10.1016/j.numecd.2012.07.010. PMC 3578131. PMID 23149075.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089060 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032754 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1".

[pmid14625281-6] Cai X, Lytton J (February 2004). "Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6". The Journal of Biological Chemistry. 279 (7): 5867–76. doi:10.1074/jbc.M310908200. PMID 14625281.

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Function

References

Further reading