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Protein-coding gene in the species Homo sapiens
Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene .[ 5] [ 6]
SIN3B has been shown to interact with HDAC1 ,[ 7] [ 8] Zinc finger and BTB domain-containing protein 16 ,[ 9] SUDS3 [ 10] IKZF1 .[ 8] [ 11]
^ a b c GRCh38: Ensembl release 89: ENSG00000127511 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031622 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Research . 5 (3): 169–76. doi :10.1093/dnares/5.3.169 PMID 9734811 . ^ "Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)" .^ Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation" . Genes & Development . 13 (15): 1924–35. doi :10.1101/gad.13.15.1924 . PMC 316920 PMID 10444591 . ^ a b Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes" . The EMBO Journal . 18 (11): 3090–100. doi :10.1093/emboj/18.11.3090 . PMC 1171390 PMID 10357820 . ^ David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene . 16 (19): 2549–56. doi :10.1038/sj.onc.1202043 . PMID 9627120 . S2CID 655636 . ^ Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex" . Molecular and Cellular Biology . 22 (8): 2743–50. doi :10.1128/MCB.22.8.2743-2750.2002 . PMC 133736 PMID 11909966 . ^ Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros" . The Journal of Biological Chemistry . 277 (31): 27697–705. doi :10.1074/jbc.M201694200 PMID 12015313 .
Ayer DE, Lawrence QA, Eisenman RN (Mar 1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3" . Cell . 80 (5): 767–76. doi :10.1016/0092-8674(95)90355-0 PMID 7889570 . S2CID 8749951 . David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene . 16 (19): 2549–56. doi :10.1038/sj.onc.1202043 . PMID 9627120 . S2CID 655636 . Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes" . The EMBO Journal . 18 (11): 3090–100. doi :10.1093/emboj/18.11.3090 . PMC 1171390 PMID 10357820 . Naruse Y, Aoki T, Kojima T, Mori N (Nov 1999). "Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes" . Proceedings of the National Academy of Sciences of the United States of America . 96 (24): 13691–6. Bibcode :1999PNAS...9613691N . doi :10.1073/pnas.96.24.13691 PMC 24126 PMID 10570134 . Spronk CA, Tessari M, Kaan AM, Jansen JF, Vermeulen M, Stunnenberg HG, Vuister GW (Dec 2000). "The Mad1-Sin3B interaction involves a novel helical fold". Nature Structural Biology . 7 (12): 1100–4. doi :10.1038/81944 . PMID 11101889 . S2CID 12451972 . Spronk CA, Jansen JF, Tessari M, Kaan AM, Aelen J, Lasonder E, Stunnenberg HG, Vuister GW (Apr 2001). "Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1". Journal of Biomolecular NMR . 19 (4): 377–8. doi :10.1023/A:1011262214741 . hdl :2066/79476 PMID 11370785 . S2CID 31789681 . Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex" . Molecular and Cellular Biology . 22 (8): 2743–50. doi :10.1128/MCB.22.8.2743-2750.2002 . PMC 133736 PMID 11909966 . Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD (Apr 2002). "E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex" . Genes & Development . 16 (8): 933–47. doi :10.1101/gad.969202 . PMC 152357 PMID 11959842 . Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros" . The Journal of Biological Chemistry . 277 (31): 27697–705. doi :10.1074/jbc.M201694200 PMID 12015313 . Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA (Feb 2003). "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B" . The Biochemical Journal . 369 (Pt 3): 651–7. doi :10.1042/BJ20020854 . PMC 1223118 PMID 12398767 . Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A (May 2003). "The histone deacetylase 9 gene encodes multiple protein isoforms" . The Journal of Biological Chemistry . 278 (18): 16059–72. doi :10.1074/jbc.M212935200 PMID 12590135 . Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1" . Genes & Development . 17 (7): 896–911. doi :10.1101/gad.252103 . PMC 196026 PMID 12670868 . Dugast-Darzacq C, Pirity M, Blanck JK, Scherl A, Schreiber-Agus N (Nov 2004). "Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential". Oncogene . 23 (55): 8887–99. doi :10.1038/sj.onc.1208107 . PMID 15467743 . S2CID 30045920 . Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S (Oct 2005). "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex" . Molecular and Cellular Biology . 25 (19): 8415–29. doi :10.1128/MCB.25.19.8415-8429.2005 . PMC 1265755 PMID 16166625 . Xu Y, Sengupta PK, Seto E, Smith BD (Apr 2006). "Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression" . The Journal of Biological Chemistry . 281 (14): 9260–70. doi :10.1074/jbc.M511724200 PMC 1434794 PMID 16464847 .
PDB gallery
1e91 : STRUCTURE OF THE COMPLEX OF THE MAD1-SIN3B INTERACTION DOMAINS
1pd7 : Extended SID of Mad1 bound to the PAH2 domain of mSin3B
2cr7 : Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B
2czy : Solution structure of the NRSF/REST-mSin3B PAH1 complex
2f05 : Solution structure of free PAH2 domain of mSin3B
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
