SIDT1

SIDT1
Identifiers
Aliases	SIDT1, B830021E24Rik, SID-1, SID1, SID1 transmembrane family member 1
External IDs	OMIM: 606816; MGI: 2443155; HomoloGene: 41189; GeneCards: SIDT1; OMA:SIDT1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	113,629,575 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	44,153,559 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; rectum; ; mucosa of sigmoid colon; ; granulocyte; ; right frontal lobe; ; tonsil; ; lymph node; ; spleen; ; gallbladder; ; dorsolateral prefrontal cortex;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; lacrimal gland; ; dentate gyrus of hippocampal formation granule cell; ; primary motor cortex; ; parotid gland; ; zygote; ; cerebellar cortex; ; submandibular gland; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA transmembrane transporter activity; RNA binding; double-stranded RNA binding;
Cellular component	membrane; integral component of membrane; lysosome; plasma membrane;
Biological process	dsRNA transport; RNA transport;
	Sources:Amigo / QuickGO
Orthologs
	54847
	320007
	ENSG00000072858
	ENSMUSG00000022696
	Q9NXL6
	Q6AXF6
NM_001308350; NM_017699; NM_001322294; NM_001322295; NM_001322296;
	NM_001322297; NM_001322298; NM_001322299; NM_001322300
	NM_001159419; NM_198034
NP_001295279; NP_001309223; NP_001309224; NP_001309225; NP_001309226;
	NP_001309227; NP_001309228; NP_001309229; NP_060169
	NP_001152891; NP_932151
	Wikidata
View/Edit Human	View/Edit Mouse

SID1 transmembrane family member 1 is a protein that in humans is encoded by the SIDT1 gene. ^[5]

Function

The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072858 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022696 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SID1 transmembrane family member 1". Retrieved 2017-10-02.

Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Elhassan MO, Christie J, Duxbury MS (2012). "Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance". J. Biol. Chem. 287 (8): 5267–77. doi:10.1074/jbc.M111.318865. PMC 3285307. PMID 22174421.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072858 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022696 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SID1 transmembrane family member 1". Retrieved 2017-10-02.

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Function

References

Further reading