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SERPINI2

From Wikipedia, the free encyclopedia
SERPINI2
Identifiers
AliasesSERPINI2, MEPI, PANCPIN, PI14, TSA2004, serpin family I member 2
External IDsOMIM: 605587; MGI: 1915181; HomoloGene: 21248; GeneCards: SERPINI2; OMA:SERPINI2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006217
NM_001012303
NM_001394327

NM_026460

RefSeq (protein)

NP_001012303
NP_006208

NP_080736

Location (UCSC)Chr 3: 167.44 – 167.48 MbChr 3: 75.15 – 75.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.[5][6]

Function

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The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114204Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034139Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y (July 1998). "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells". Genes, Chromosomes & Cancer. 22 (3): 179–85. doi:10.1002/(SICI)1098-2264(199807)22:3<179::AID-GCC3>3.0.CO;2-T. PMID 9624529. S2CID 9525421.
  6. ^ a b "Entrez Gene: SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2".

Further reading

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  • The MEROPS online database for peptidases and their inhibitors: I04.026