SEMA4A

SEMA4A
Identifiers
Aliases	SEMA4A, CORD10, RP35, SEMAB, SEMB, semaphorin 4A
External IDs	OMIM: 607292; MGI: 107560; HomoloGene: 8425; GeneCards: SEMA4A; OMA:SEMA4A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,177,752 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,368,489 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; bone marrow cells; ; blood; ; amygdala; ; nucleus accumbens; ; skin of abdomen; ; left lobe of thyroid gland; ; retinal pigment epithelium; ; cingulate gyrus;
	Top expressed in
	granulocyte; ; Paneth cell; ; retinal pigment epithelium; ; ventromedial nucleus; ; jejunum; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; prostate; ; ileum; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; neuropilin binding; semaphorin receptor binding; chemorepellent activity;
Cellular component	integral component of membrane; nucleus; cytosol; intracellular membrane-bounded organelle; plasma membrane; extracellular space; membrane; integral component of plasma membrane;
Biological process	cell differentiation; adaptive immune response; axonogenesis; immune system process; T-helper 1 cell differentiation; nervous system development; multicellular organism development; angiogenesis; regulation of endothelial cell migration; regulation of cell shape; negative regulation of angiogenesis; T cell differentiation involved in immune response; semaphorin-plexin signaling pathway; negative chemotaxis; neural crest cell migration; positive regulation of cell migration; negative regulation of axon extension involved in axon guidance; positive regulation of excitatory synapse assembly; positive regulation of inhibitory synapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	64218
	20351
	ENSG00000196189
	ENSMUSG00000028064
	Q9H3S1
	Q62178
NM_001193300; NM_001193301; NM_001193302; NM_022367; NM_001370567;
	NM_001370568; NM_001370569; NM_001370571
	NM_001163489; NM_001163490; NM_001163491; NM_013658
NP_001180229; NP_001180230; NP_001180231; NP_071762; NP_001357496;
	NP_001357497; NP_001357498; NP_001357500
	NP_001156961; NP_001156962; NP_001156963; NP_038686
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.^[5]^[6]

Function

SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM]^[6]

Clinical significance

A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.^[7]

Recently it has been identified as a novel therapeutic target in Multiple myeloma.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196189 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028064 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–948. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
^ ^a ^b "Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A".
^ Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, et al. (October 2014). "Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X". Nature Communications. 5: 5191. Bibcode:2014NatCo...5.5191S. doi:10.1038/ncomms6191. PMC 4214414. PMID 25307848.
^ Anderson GS, Ballester-Beltran J, Giotopoulos G, Guerrero JA, Surget S, Williamson JC, et al. (April 2022). "Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma". Blood. 139 (16): 2471–2482. doi:10.1182/blood.2021015161. PMC 11022854. PMID 35134130.

Kikutani H, Kumanogoh A (February 2003). "Semaphorins in interactions between T cells and antigen-presenting cells". Nature Reviews. Immunology. 3 (2): 159–167. doi:10.1038/nri1003. PMID 12563299. S2CID 33203042.
Kumanogoh A, Kikutani H (September 2003). "Immune semaphorins: a new area of semaphorin research". Journal of Cell Science. 116 (Pt 17): 3463–3470. doi:10.1242/jcs.00674. PMID 12893810.
Elhabazi A, Marie-Cardine A, Chabbert-de Ponnat I, Bensussan A, Boumsell L (2004). "Structure and function of the immune semaphorin CD100/SEMA4D". Critical Reviews in Immunology. 23 (1–2): 65–81. doi:10.1615/CritRevImmunol.v23.i12.40. PMID 12906260.
Kumanogoh A, Marukawa S, Suzuki K, Takegahara N, Watanabe C, Ch'ng E, et al. (October 2002). "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2". Nature. 419 (6907): 629–633. Bibcode:2002Natur.419..629K. doi:10.1038/nature01037. PMID 12374982. S2CID 4431066.
Abid A, Ismail M, Mehdi SQ, Khaliq S (April 2006). "Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases". Journal of Medical Genetics. 43 (4): 378–381. doi:10.1136/jmg.2005.035055. PMC 2563224. PMID 16199541.
Nkyimbeng-Takwi E, Chapoval SP (May 2011). "Biology and function of neuroimmune semaphorins 4A and 4D". Immunologic Research. 50 (1): 10–21. doi:10.1007/s12026-010-8201-y. PMC 3366695. PMID 21203905.
Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (May 2011). "Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor". BMC Immunology. 12: 30. doi:10.1186/1471-2172-12-30. PMC 3118960. PMID 21595947.
Nkyimbeng-Takwi EH, Shanks K, Smith E, Iyer A, Lipsky MM, Detolla LJ, et al. (July 2012). "Neuroimmune semaphorin 4A downregulates the severity of allergic response". Mucosal Immunology. 5 (4): 409–419. doi:10.1038/mi.2012.18. PMC 3378810. PMID 22472774.
Mogie G, Shanks K, Nkyimbeng-Takwi EH, Smith E, Davila E, Lipsky MM, et al. (November 2013). "Neuroimmune semaphorin 4A as a drug and drug target for asthma". International Immunopharmacology. 17 (3): 568–575. doi:10.1016/j.intimp.2013.08.005. PMC 3818409. PMID 23994348.
Chapoval SP (November 2015). "Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis". Arthritis Research & Therapy. 17: 313. doi:10.1186/s13075-015-0846-4 (inactive 1 November 2024). PMC 4635990. PMID 26542940.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196189 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028064 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7748561-5] Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–948. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.

[entrez-6] "Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A".

[pmid25307848-7] Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, et al. (October 2014). "Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X". Nature Communications. 5: 5191. Bibcode:2014NatCo...5.5191S. doi:10.1038/ncomms6191. PMC 4214414. PMID 25307848.

[pmid-8] Anderson GS, Ballester-Beltran J, Giotopoulos G, Guerrero JA, Surget S, Williamson JC, et al. (April 2022). "Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma". Blood. 139 (16): 2471–2482. doi:10.1182/blood.2021015161. PMC 11022854. PMID 35134130.

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Function

Clinical significance

References

Further reading