SARDH

SARDH
Identifiers
Aliases	SARDH, BPR-2, DMGDHL1, SAR, SARD, SDH, sarcosine dehydrogenase
External IDs	OMIM: 604455; MGI: 2183102; HomoloGene: 5149; GeneCards: SARDH; OMA:SARDH - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,739,955 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	27,138,349 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; buccal mucosa cell; ; body of pancreas; ; corpus epididymis; ; human kidney; ; testicle; ; granulocyte; ; ventricular zone; ; sural nerve; ; ganglionic eminence;
	Top expressed in
	left lobe of liver; ; right kidney; ; proximal tubule; ; human kidney; ; yolk sac; ; external carotid artery; ; major salivary gland; ; parotid gland; ; lip; ; internal carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; sarcosine dehydrogenase activity;
Cellular component	mitochondrion; mitochondrial matrix; cytoplasm;
Biological process	choline catabolic process; sarcosine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1757
	192166
	ENSG00000123453
	ENSMUSG00000009614
	Q9UL12
	Q99LB7
	NM_001134707; NM_007101
	NM_138665
	NP_001128179; NP_009032
	NP_619606
	Wikidata
View/Edit Human	View/Edit Mouse

Sarcosine dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the SARDH gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123453 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009614 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eschenbrenner M, Jorns MS (Nov 1999). "Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia". Genomics. 59 (3): 300–8. doi:10.1006/geno.1999.5886. PMID 10444331.
^ "Entrez Gene: SARDH sarcosine dehydrogenase".

Porter DH, Cook RJ, Wagner C (1986). "Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver". Arch. Biochem. Biophys. 243 (2): 396–407. doi:10.1016/0003-9861(85)90516-8. PMID 2417560.
London RE, Gabel SA, Funk A (1988). "Metabolism of excess methionine in the liver of intact rat: an in vivo 2H NMR study". Biochemistry. 26 (22): 7166–72. doi:10.1021/bi00396a044. PMID 2447942.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bergeron F, Otto A, Blache P, et al. (1998). "Molecular cloning and tissue distribution of rat sarcosine dehydrogenase". Eur. J. Biochem. 257 (3): 556–61. doi:10.1046/j.1432-1327.1998.2570556.x. PMID 9839943.
Gilbert JR, Kumar A, Newey S, et al. (2000). "Physical and cDNA mapping in the DBH region of human chromosome 9q34". Hum. Hered. 50 (3): 151–7. doi:10.1159/000022905. PMID 10686491. S2CID 43238824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123453 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009614 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10444331-5] Eschenbrenner M, Jorns MS (Nov 1999). "Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia". Genomics. 59 (3): 300–8. doi:10.1006/geno.1999.5886. PMID 10444331.

[entrez-6] "Entrez Gene: SARDH sarcosine dehydrogenase".

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References

Further reading