SAA4

SAA4
Identifiers
Aliases	SAA4, C-SAA, CSAA, serum amyloid A4, constitutive
External IDs	OMIM: 104752; MGI: 98224; GeneCards: SAA4; OMA:SAA4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	18,236,802 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	46,382,027 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; olfactory zone of nasal mucosa; ; minor salivary glands; ; lactiferous gland; ; anterior pituitary; ; Descending thoracic aorta; ; tonsil; ; gastrocnemius muscle; ; appendix; ; gallbladder;
	Top expressed in
	left lobe of liver; ; gallbladder; ; human fetus; ; thoracic diaphragm; ; ureter; ; proximal tubule; ; lower limb muscles; ; yolk sac; ; muscle of leg; ; medial head of gastrocnemius muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	chemoattractant activity;
Cellular component	extracellular region; extracellular exosome; high-density lipoprotein particle; extracellular space;
Biological process	cell chemotaxis; acute-phase response; positive chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6291
	20211
	ENSG00000148965
	ENSMUSG00000040017
	P35542
	P31532
	NM_006512
	NM_011316
	NP_006503
	NP_035446
	Wikidata
View/Edit Human	View/Edit Mouse

Serum amyloid A4, constitutive is a protein that in humans is encoded by the SAA4 gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148965 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040017 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Serum amyloid A4, constitutive". Retrieved 2020-03-14.

Kumon Y, Suehiro T, Faulkes DJ, Hosakawa T, Ikeda Y, Woo P, et al. (November 2002). "Transcriptional regulation of serum amyloid A1 gene expression in human aortic smooth muscle cells involves CCAAT/enhancer binding proteins (C/EBP) and is distinct from HepG2 cells". Scandinavian Journal of Immunology. 56 (5): 504–11. doi:10.1046/j.1365-3083.2002.01169.x. PMID 12410800. S2CID 12571753.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, et al. (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". American Journal of Human Genetics. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, et al. (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes and Immunity. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Murphy CL, Wang S, Kestler DP, Stevens FA, Weiss DT, Solomon A (2009). "AA amyloidosis associated with a mutated serum amyloid A4 protein". Amyloid. 16 (2): 84–8. doi:10.1080/13506120902879905. PMID 20536400. S2CID 205766178.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, et al. (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
Peloso GM, Demissie S, Collins D, Mirel DB, Gabriel SB, Cupples LA, et al. (December 2010). "Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease". Journal of Lipid Research. 51 (12): 3524–32. doi:10.1194/jlr.P008268. PMC 2975725. PMID 20855565.
Chen CL, Lin TS, Tsai CH, Wu CC, Chung T, Chien KY, et al. (June 2013). "Identification of potential bladder cancer markers in urine by abundant-protein depletion coupled with quantitative proteomics". Journal of Proteomics. 85: 28–43. doi:10.1016/j.jprot.2013.04.024. PMID 23631828.
Rossmann C, Hammer A, Koyani CN, Kovacevic A, Siwetz M, Desoye G, et al. (August 2014). "Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells". Placenta. 35 (8): 661–4. doi:10.1016/j.placenta.2014.05.012. PMC 4119475. PMID 24951172.
Seok A, Lee HJ, Lee S, Lee J, Mun S, Park A, et al. (May 2017). "Identification and Validation of SAA4 as a Rheumatoid Arthritis Prescreening Marker by Liquid Chromatography Tandem-mass Spectrometry". Molecules. 22 (5): 805. doi:10.3390/molecules22050805. PMC 6154608. PMID 28505104.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148965 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040017 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Serum amyloid A4, constitutive". Retrieved 2020-03-14.

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References

Further reading