S100A14

S100A14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M0R
Identifiers
Aliases	S100A14, BCMP84, S100A15, S100 calcium binding protein A14
External IDs	OMIM: 607986; MGI: 1913416; HomoloGene: 10781; GeneCards: S100A14; OMA:S100A14 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,616,986 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,436,144 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; mucosa of transverse colon; ; skin of abdomen; ; oral cavity; ; body of tongue; ; skin of leg; ; gums; ; rectum; ; gingival epithelium; ; vulva;
	Top expressed in
	esophagus; ; lip; ; skin of abdomen; ; skin of external ear; ; epidermis; ; hair follicle; ; skin of back; ; pyloric antrum; ; mucous cell of stomach; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; chemokine receptor binding; calcium ion binding;
Cellular component	cell junction; perinuclear region of cytoplasm; extracellular exosome; cytoplasm; cytosol; nuclear body; plasma membrane;
Biological process	positive regulation of monocyte chemotaxis; response to lipopolysaccharide; calcium ion homeostasis; apoptotic process; toll-like receptor 4 signaling pathway; defense response to bacterium; positive regulation of granulocyte chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	57402
	66166
	ENSG00000189334
	ENSMUSG00000042306
	Q9HCY8
	Q9D2Q8
	NM_020672
	NM_001163525; NM_001163526; NM_025393
	NP_065723
	NP_001156997; NP_001156998; NP_079669
	Wikidata
View/Edit Human	View/Edit Mouse

S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene.^[5]

Function

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000189334 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042306 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: S100 calcium binding protein A14".
^ Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY (Jan 2010). "Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports. 23 (1): 45–52. doi:10.3892/or_00000604. PMID 19956863.
^ Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z (Apr 2009). "Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma". Cancer Research. 69 (8): 3451–7. doi:10.1158/0008-5472.CAN-08-4231. PMID 19351828.

Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (Feb 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH (Jul 2008). "Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15". Journal of Immunology. 181 (2): 1499–1506. doi:10.4049/jimmunol.181.2.1499. PMC 2435511. PMID 18606705.
Stemmler S, Nothnagel M, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S (Aug 2009). "Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients". International Journal of Immunogenetics. 36 (4): 217–22. doi:10.1111/j.1744-313X.2009.00858.x. PMID 19601998. S2CID 38130688.
Jin Q, Chen H, Luo A, Ding F, Liu Z (2011). "S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)". PLOS ONE. 6 (4): e19375. Bibcode:2011PLoSO...619375J. doi:10.1371/journal.pone.0019375. PMC 3084824. PMID 21559403.
Büchau AS, Hassan M, Kukova G, Lewerenz V, Kellermann S, Würthner JU, Wolf R, Walz M, Gallo RL, Ruzicka T (Nov 2007). "S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4". The Journal of Investigative Dermatology. 127 (11): 2596–604. doi:10.1038/sj.jid.5700946. PMID 17625598.
Sapkota D, Costea DE, Blø M, Bruland O, Lorens JB, Vasstrand EN, Ibrahim SO (Mar 2012). "S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest". Oral Oncology. 48 (3): 219–25. doi:10.1016/j.oraloncology.2011.10.001. PMID 22032898.
Boeshans KM, Wolf R, Voscopoulos C, Gillette W, Esposito D, Mueser TC, Yuspa SH, Ahvazi B (May 2006). "Purification, crystallization and preliminary X-ray diffraction of human S100A15". Acta Crystallographica Section F. 62 (Pt 5): 467–470. doi:10.1107/S1744309106012838. PMC 2219979. PMID 16682778.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000189334 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042306 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: S100 calcium binding protein A14".

[6] Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY (Jan 2010). "Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports. 23 (1): 45–52. doi:10.3892/or_00000604. PMID 19956863.

[7] Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z (Apr 2009). "Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma". Cancer Research. 69 (8): 3451–7. doi:10.1158/0008-5472.CAN-08-4231. PMID 19351828.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Function

References

Further reading