Rosalind Lee
Rosalind Lee | |
|---|---|
| Alma mater | Massachusetts Institute of Technology |
| Known for | Discovery of microRNA |
| Awards | Newcomb Cleveland Prize (2003) |
| Scientific career | |
| Institutions | Harvard University Dartmouth College UMass Chan Medical School |
Rosalind 'Candy' Lee is a biomedical scientist, best known for her breakthrough paper on the discovery of microRNA which was published in 1993.[1] In 2002, Lee was joint receipient of the Newcomb Cleveland Prize, for the best paper published in the journal Science that year.[2] In 2024, Lee's 1993 paper was cited as the seminal discovery for which the Nobel Prize in physiology or medicine was awarded that year, to co-author Victor Ambros.[3]
Career
[edit]Lee graduated from Massachusetts Institute of Technology in 1976.[4] That same year, she married Victor Ambros, who was at that time a PhD student at MIT.[5]
Lee began working as a research assistant in Victor Ambros' lab in 1987. Her work on the cloning of lin-4 began in 1989, in Ambros's lab at Harvard University, and she was joined on the project later by Rhonda Feinbaum. In a later paper, Lee describes how they eventually wrote up the work in 1993, and submitted it to the journal Cell, in parallel with a related paper by Gary Ruvkun.[6] Lee's paper was soon accepted for publication, and in a change of journal policy, it was published with a notice on the front page that it was jointly first-authored by Lee and Feinbaum.[6] Lee's 1993 paper is widely regarded as the seminal contribution in the discovery of microRNA, for which her husband Ambros, and Ruvkun, were both awarded the Nobel Prize in 2024.[3] The Nobel announcement provoked interest into the question of why Lee hadn't also been recognised with the award.[7]
In 2002, Lee was joint recipient of the Newcomb Cleveland Prize of the American Association for the Advancement of Science, for her first-author paper in Science that reported the discovery of 15 new microRNA genes in C. elegans.[8]
References
[edit]- ^ Lee, Rosalind C.; Feinbaum, Rhonda L.; Ambros, Victor (December 3, 1993). "The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14". Cell. 75 (5): 843–854. doi:10.1016/0092-8674(93)90529-Y – via ScienceDirect.
- ^ "Dartmouth Medicine Magazine - Publications". dartmed.dartmouth.edu.
- ^ a b "The Nobel Prize in Physiology or Medicine 2024". NobelPrize.org.
- ^ "Donors Help to Build STEM Opportunities for Young People". MIT for a Better World.
- ^ "Dr. Paul Janssen Award". Dr. Paul Janssen Award.
- ^ a b Lee, Rosalind; Feinbaum, Rhonda; Ambros, Victor (January 23, 2004). "A short history of a short RNA". Cell. 116: S89–S92. doi:10.1016/S0092-8674(04)00035-2 – via ScienceDirect.
- ^ Domínguez, Nuño (October 8, 2024). "Why researcher Rosalind Lee, the wife of the Nobel Prize winner in Medicine, didn't receive the award as well?". EL PAÍS English.
- ^ Lee, Rosalind C.; Ambros, Victor (October 26, 2001). "An Extensive Class of Small RNAs in Caenorhabditis elegans". Science. 294 (5543): 862–864. doi:10.1126/science.1065329 – via CrossRef.