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Roberto Paganelli

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Roberto Paganelli
Born
Italy
NationalityItalian
Occupation(s)Physician, clinical immunologist and academic
Academic background
EducationMedical Degree, 1976
Specialization in Allergy and Clinical Immunology
Alma materUniersita’ La Sapienza

Roberto Paganelli is an Italian physician, clinical immunologist and academic. He formerly was a Professor of Internal Medicine at the D'Annunzio University of Chieti–Pescara.[1]

Paganelli is most known for his work on allergy, immunology, inflammatory responses, mesenchymal stem cells and immunosenescence, and focusing on food allergy, immune complex diseases, immunoglobulin deficiencies, T-cell defects, and internal medicine.[2]

Paganelli is the section editor-in-chief for the journal Pathogens.[3]

Education

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Paganelli obtained his medical degree from Universita La Sapienza in 1976 and completed his specialization in Allergy and Clinical Immunology in 1984 from the same university.[4]

Career

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After an internship at the 3rd Medical Clinic of the Universita La Sapienza in Rome, Paganelli spent four years as a Research Fellow at the UCL Great Ormond Street Institute of Child Health under the supervision of J.F. Soothill and R.J. Levinsky, until 1982 . He then began his academic journey in 1983, by joining the Università degli Studi dell'Aquila as an assistant professor, a role he held until 1984. In November 1984, he became part of the Universita’ La Sapienza, where he served as an assistant professor until 1999. Later, he joined Universita’ G. D’Annunzio and held the position of associate professor of Internal Medicine from 1999 to 2004, followed by a subsequent appointment as professor from 2004 to 2021.[1]

At Universita’ G. D’Annunzio, Paganelli held multiple appointments, notably as the director of the School of Specialization in Rheumatology from 2007 to 2014, and the director of the School of Specialization in Allergy and Clinical Immunology from 2017 to 2021.

Paganelli serves as the section editor-in-chief for the journal Pathogens.[3] He has served on the boards of Italian Society of Allergy and Asthma. He also served on the Immunodeficiency Committee at the World Allergy Organization.

Research

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Paganelli's research has focused on the Immune system, allergic diseases, and immunopathology investigations. He has authored numerous publications spanning the areas of clinical immunology, inflammatory responses, and immunosenescence including over 250 articles in peer-reviewed journals.[2]

Immunology

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Paganelli's immunology research has provided insights into the immune system's intricacies and its role in health and disease. Centered on immune complex formation in patients with allergies and parasitic infections,[5][6][7] his work demonstrated diverse immune responses to food proteins based on factors like age, health status, and allergies[8] and devised a two-step technique to detect specific antigens in serum sample immune complexes.[9] His research into the involvement of immune complexes in atopic dermatitis (AD)[10] revealed that while immune system imbalances are present in AD, these disparities might be consequential rather than the fundamental cause of the condition.[11] Furthermore, his investigation into the impacts of prolonged exposure to electromagnetic fields (ELMFs) from radio and television broadcasting stations on women's immune systems revealed diminished levels of diverse immune cell types, coupled with reduced production of crucial immune-regulating molecules.[12] In collaborative research with several groups, he explored the impact of various metallic compounds on peripheral blood mononuclear cells, revealing that the cytotoxicity of these compounds is contingent upon their chemical speciation.[13]

Paganelli's research has also focused on clinical immunology, notably examining the enduring effects of thymectomy on myasthenia gravis[14] patients and assessing the allergenic properties of specific consumables like goat milk for certain groups - especially children.[15] Most studies were done in Rome, while in Fernando Aiuti's Lab, and collaborations with local groups and scientists across Europe, where he organized the first meeting of the future European Society of Immunodeficiencies, and was on the steering Committee of the European Registry for Primary Immunodeficiencies. Focusing his research efforts on genetic factors in immunodeficiency, his 2005 study linked positive family history to a higher risk for immunoglobulin A deficiency and common variable immunodeficiency.[16] Furthermore, his analysis of patients with ataxia-telangiectasia revealed a range of immune system abnormalities including deficiencies in specific helper T-cell subpopulations, intrinsic B-cell defects, modified suppressor T-cell activity, and impaired immunoglobulin production.[17]

Inflammatory responses

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Paganelli's research has explored the cellular and molecular mechanisms underlying inflammatory responses. In collaboration with GA Rabinovich, he investigated the extracellular and intracellular functions of galectins and provided insights into mechanisms for controlling cellular processes such as proliferation, signal transduction, and cell death.[18] His 2009 study on tendinopathy pathogenesis highlighted the collaborative relationship between inflammation and degeneration and proposed that overuse-induced micro-tears in tendon fibers lead to a dynamic interplay of healing processes, inflammation, neovascularization, and nerve growth.[19] Focusing on the correlation between aging, obesity, and inflammatory age-related ailments, his work examined how immune cells penetrate adipose tissue in cases of obesity, triggering inflammation and shifts in metabolism.[20] Furthermore, his research contributed to the understanding pertaining to the immune response directed against the cow's milk antigen beta-lactoglobulin (beta-LG) within individuals affected by inflammatory bowel disease[21] and explored the correlation between food antigens, inflammation, and rheumatoid arthritis.[22] In his investigation of age-related decline in nerve conduction velocity (NCV) in the peripheral nervous system, his study found an association between reduced NCV, elevated inflammatory markers, and low Vitamin E levels, indicating that inflammation and oxidative stress might expedite the deterioration of peripheral nervous system function during aging.[23] More recently in 2021, he assessed the impact of a 3-month diet excluding meat, gluten, and lactose on patients with longstanding rheumatoid arthritis, revealing reduced circulating leukocytes and neutrophils, along with lowered hs-CRP levels, indicating improved inflammation control.[24] His more recent studies highlight the usefulness of Neutrophil-to-Lymphocyte ratios in assessing the resilience of the immune system in diseases and ageing.[25]

Immunosenescence

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Paganelli's immunosenescence research has contributed to the identification and characterization of various cytokines, their signaling pathways, and their release patterns.[26][27] His collaborative work with Claudio Franceschi, Fagiolo and others revealed that both young and aged individuals maintain the ability of peripheral mononuclear cells to produce pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1 beta) when stimulated, potentially impacting age-related pathological processes.[28][29] In his evaluation of cytokine and chemokine expression in systemic sclerosis (SSc) patients using various biological specimens, his study established a correlation between certain cytokines and organ involvement, indicating that IL-6, IL-10, MDC, and MCP-1 exhibited varying associations with internal organ involvement.[30] While investigating the immune profiles of healthy centenarians, he revealed altered T cell clone patterns in comparison to younger individuals, including a decreased prevalence of the Th1 pattern in CD4+ T cells,[31] and also highlighted the complex cytokine environment changes accompanying the aging process.[32] In his assessment of factors impacting Interleukin-1 beta (IL-1β) serum levels within a sizable and diverse population, he determined that these levels correlated with congestive heart failure, angina, serum Ca2+ levels, and a history of dyslipidemia.[33] His 2019 study focused on the serological cytokine profile in cutaneous melanoma, underscoring the viable employment of these agents as indicators for tracking disease advancement and gauging therapeutic efficacy.[34] His work in 2023 examined the immune alterations distinguishing different types of dementia and the role of responses to amyloid A-beta.[35]

Selected articles

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  • Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., ... & Paganelli, R. (1993). Increased cytokine production in mononuclear cells of healthy elderly people. European journal of immunology, 23(9), 2375–2378.
  • Bellioni-Businco, B., Paganelli, R., Lucenti, P., Giampietro, P. G., Perbornc, H., & Businco, L. (1999). Allergenicity of goat's milk in children with cow's milk allergy. Journal of Allergy and Clinical Immunology, 103(6), 1191–1194.
  • Rabinovich, G. A., Baum, L. G., Tinari, N., Paganelli, R., Natoli, C., Liu, F. T., & Iacobelli, S. (2002). Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?. Trends in immunology, 23(6), 313–320.
  • Giovannetti, A., Pierdominici, M., Mazzetta, F., Marziali, M., Renzi, C., Mileo, A. M., ... & Aiuti, F. (2007). Unravelling the complexity of T cell abnormalities in common variable immunodeficiency. The Journal of Immunology, 178(6), 3932–3943.
  • Abate, M., Gravare Silbernagel, K., Siljeholm, C., Di Iorio, A., De Amicis, D., Salini, V., ... & Paganelli, R. (2009). Pathogenesis of tendinopathies: inflammation or degeneration?. Arthritis research & therapy, 11(3), 1–15.

References

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  1. ^ a b "PAGANELLI Roberto | Università degli Studi "G. d'Annunzio" Chieti - Pescara". cn.unich.it.
  2. ^ a b "Roberto PAGANELLI". scholar.google.com.
  3. ^ a b "Pathogens". www.mdpi.com.
  4. ^ "Paganelli Roberto".
  5. ^ Paganelli, R.; Levinsky, R. J.; Brostoff, J.; Wraith, D. G. (June 16, 1979). "Immune complexes containing food proteins in normal and atopic subjects after oral challenge and effect of sodium cromoglycate on antigen absorption". Lancet. 1 (8129): 1270–1272. doi:10.1016/s0140-6736(79)92230-x. PMID 87729. S2CID 39696558.
  6. ^ Paganelli, R.; Atherton, D. J.; Levinsky, R. J. (March 31, 1983). "Differences between normal and milk allergic subjects in their immune responses after milk ingestion". Archives of Disease in Childhood. 58 (3): 201–206. doi:10.1136/adc.58.3.201. PMC 1627834. PMID 6601473.
  7. ^ Paganelli, R.; Ngu, J. L.; Levinsky, R. J. (March 31, 1980). "Circulating immune complexes in onchocerciasis". Clinical and Experimental Immunology. 39 (3): 570–575. PMC 1538140. PMID 7379329.
  8. ^ Levinsky, R. J.; Paganelli, R.; Robertson, D. M.; Atherton, D. J. (August 31, 1981). Bourne, F. J. (ed.). The Mucosal Immune System: Proceedings of a Seminar in the EEC Programme of Coordination of Agricultural Research on Protection of the Young Animal against Perinatal Diseases, held at the University of Bristol, School of Veterinary Science, Langford, Nr. Bristol, United Kingdom on September 9–11, 1980. Springer Netherlands. pp. 154–180. doi:10.1007/978-94-009-8331-1_8 – via Springer Link.
  9. ^ Paganelli, R.; Levinsky, R. J.; Atherton, D. J. (October 31, 1981). "Detection of specific antigen within circulating immune complexes: validation of the assay and its application to food antigen-antibody complexes formed in healthy and food-allergic subjects". Clinical and Experimental Immunology. 46 (1): 44–53. PMC 1536342. PMID 6896019.
  10. ^ Paganelli, R.; Scala, E.; Guerra, E.; Quinti, I. (August 31, 1989). "Role of immune complexes in atopic dermatitis". Allergy. 44 (Suppl 9): 65–69. doi:10.1111/j.1398-9995.1989.tb02458.x. PMID 2683844.
  11. ^ G, Fabrizi; A, Romano; P, Vultaggio; S, Bellegrandi; R, Paganelli; A, Venuti (July 31, 1999). "Heterogeneity of atopic dermatitis defined by the immune response to inhalant and food allergens". European Journal of Dermatology. 9 (5): 380–384. PMID 10417442.
  12. ^ Boscol, P.; Di Sciascio, M. B.; D'Ostilio, S.; Del Signore, A.; Reale, M.; Conti, P.; Bavazzano, P.; Paganelli, R.; Di Gioacchino, M. (June 12, 2001). "Effects of electromagnetic fields produced by radiotelevision broadcasting stations on the immune system of women". The Science of the Total Environment. 273 (1–3): 1–10. Bibcode:2001ScTEn.273....1B. doi:10.1016/s0048-9697(01)00815-4. PMID 11419593.
  13. ^ Russi, M.; Meliddo, G.; Toto, E.; Di Giampaolo, L.; Travaglino, P.; Appignani, M.; Di Gioacchino, M.; Boscolo, P. (August 31, 2003). "[Comparative in vitro study of various titanium compounds on the immune system]". Giornale Italiano di Medicina del Lavoro ed Ergonomia. 25 Suppl (3): 69–70. PMID 14979088.
  14. ^ Gerli, R.; Paganelli, R.; Cossarizza, A.; Muscat, C.; Piccolo, G.; Barbieri, D.; Mariotti, S.; Monti, D.; Bistoni, O.; Raiola, E.; Venanzi, F. M.; Bertotto, A.; Franceschi, C. (May 31, 1999). "Long-term immunologic effects of thymectomy in patients with myasthenia gravis". The Journal of Allergy and Clinical Immunology. 103 (5 Pt 1): 865–872. doi:10.1016/s0091-6749(99)70431-8. PMID 10329821.
  15. ^ Bellioni-Businco, B.; Paganelli, R.; Lucenti, P.; Giampietro, P. G.; Perborn, H.; Businco, L. (June 30, 1999). "Allergenicity of goat's milk in children with cow's milk allergy". The Journal of Allergy and Clinical Immunology. 103 (6): 1191–1194. doi:10.1016/s0091-6749(99)70198-3. PMID 10359905.
  16. ^ Vorechovský, I.; Zetterquist, H.; Paganelli, R.; Koskinen, S.; Webster, A. D.; Björkander, J.; Smith, C. I.; Hammarström, L. (November 30, 1995). "Family and linkage study of selective IgA deficiency and common variable immunodeficiency". Clinical Immunology and Immunopathology. 77 (2): 185–192. doi:10.1006/clin.1995.1142. PMID 7586726.
  17. ^ Fiorilli, M.; Businco, L.; Pandolfi, F.; Paganelli, R.; Russo, G.; Aiuti, F. (April 30, 1983). "Heterogeneity of immunological abnormalities in ataxia-telangiectasia". Journal of Clinical Immunology. 3 (2): 135–141. doi:10.1007/BF00915484. PMID 6222062. S2CID 20852445.
  18. ^ Rabinovich, Gabriel A.; Baum, Linda G.; Tinari, Nicola; Paganelli, Roberto; Natoli, Clara; Liu, Fu Tong; Iacobelli, Stefano (June 30, 2002). "Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?". Trends in Immunology. 23 (6): 313–320. doi:10.1016/s1471-4906(02)02232-9. hdl:11336/30710. PMID 12072371.
  19. ^ M, Abate; Kg, Silbernagel; C, Siljeholm; A, Di Iorio; D, De Amicis; V, Salini; S, Werner; R, Paganelli (August 31, 2009). "Pathogenesis of tendinopathies: inflammation or degeneration?". Arthritis Research & Therapy. 11 (3): 235. doi:10.1186/ar2723. PMC 2714139. PMID 19591655.
  20. ^ Frasca, Daniela; Blomberg, Bonnie B.; Paganelli, Roberto (December 7, 2017). "Aging, Obesity, and Inflammatory Age-Related Diseases". Frontiers in Immunology. 8: 1745. doi:10.3389/fimmu.2017.01745. PMC 5725402. PMID 29270179.
  21. ^ Paganelli, R.; Pallone, F.; Montano, S.; Le Moli, S.; Matricardi, P. M.; Fais, S.; Paoluzi, P.; D'Amelio, R.; Aiuti, F. (August 31, 1985). "Isotypic analysis of antibody response to a food antigen in inflammatory bowel disease". International Archives of Allergy and Applied Immunology. 78 (1): 81–85. doi:10.1159/000233867. PMID 2863223.
  22. ^ Fiocco, U.; Fagiolo, U.; Paganelli, R.; Cozzi, L.; Rosada, M.; Cozzi, E.; Lama, M.; Todesco, S. (August 31, 1992). Rainsford, K. D.; Velo, G. P. (eds.). Side-Effects of Anti-Inflammatory Drugs 3. Springer Netherlands. pp. 69–79. doi:10.1007/978-94-011-2982-4_11 – via Springer Link.
  23. ^ Iorio, Angelo Di; Cherubini, Antonio; Volpato, Stefano; Sparvieri, Eleonora; Lauretani, Fulvio; Franceschi, Claudio; Senin, Umberto; Abate, Giuseppe; Paganelli, Roberto; Martin, Antonio; Andres-Lacueva, Cristina; Ferrucci, Luigi (September 30, 2006). "Markers of inflammation, Vitamin E and peripheral nervous system function: The InCHIANTI study". Neurobiology of Aging. 27 (9): 1280–1288. doi:10.1016/j.neurobiolaging.2005.07.004. PMC 2646090. PMID 16112778.
  24. ^ Mt, Guagnano; C, D'Angelo; D, Caniglia; P, Di Giovanni; E, Celletti; E, Sabatini; L, Speranza; M, Bucci; F, Cipollone; R, Paganelli (October 9, 2021). "Improvement of Inflammation and Pain after Three Months' Exclusion Diet in Rheumatoid Arthritis Patients". Nutrients. 13 (10): 3535. doi:10.3390/nu13103535. PMC 8539601. PMID 34684536.
  25. ^ Pellegrino, Raffaello; Paganelli, Roberto; Iorio, Angelo Di; Bandinelli, Stefania; Moretti, Antimo; Iolascon, Giovanni; Sparvieri, Eleonora; Tarantino, Domiziano; Ferrucci, Luigi (August 3, 2023). "Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio. Results from InCHIANTI follow-up study". Research Square: rs.3.rs–3111431. doi:10.21203/rs.3.rs-3111431/v1. PMC 10350238. PMID 37461588.
  26. ^ Boscolo, Paolo; del Signore, Antonella; Sabbioni, Enrico; Di Gioacchino, Mario; Di Giampaolo, Luca; Reale, Marcella; Conti, Pio; Paganelli, Roberto; Giaccio, Mario (August 31, 2003). "Effects of resveratrol on lymphocyte proliferation and cytokine release". Annals of Clinical and Laboratory Science. 33 (2): 226–231. PMID 12817628.
  27. ^ Boscolo, Paolo; Di Giampaolo, Luca; Qiao, Niu; Reale, Marcella; Castellani, Maria Luisa; Lucci, Isabella; Travaglini, Paola; Kouri, Mary; Verna, Nicola; Volpe, Anna Rita; Carmignani, Marco; Paganelli, Roberto; Di Gioacchino, Mario (August 31, 2005). "Inhibitory effects of cadmium on peripheral blood mononuclear cell proliferation and cytokine release are reversed by zinc and selenium salts". Annals of Clinical and Laboratory Science. 35 (2): 115–120. PMID 15943174.
  28. ^ U, Fagiolo; A, Cossarizza; E, Scala; E, Fanales-Belasio; C, Ortolani; E, Cozzi; D, Monti; C, Franceschi; R, Paganelli (September 30, 1993). "Increased cytokine production in mononuclear cells of healthy elderly people". European Journal of Immunology. 23 (9): 2375–2378. doi:10.1002/eji.1830230950. PMID 8370415. S2CID 28045156.
  29. ^ Paganelli, Roberto; Di Iorio, Angelo; Patricelli, Luca; Ripani, Fausto; Sparvieri, Eleonora; Faricelli, Raffaella; Iarlori, Carla; Porreca, Ettore; Di Gioacchino, Mario; Abate, Giuseppe (August 31, 2002). "Proinflammatory cytokines in sera of elderly patients with dementia: levels in vascular injury are higher than those of mild-moderate Alzheimer's disease patients". Experimental Gerontology. 37 (2–3): 257–263. doi:10.1016/s0531-5565(01)00191-7. PMID 11772511. S2CID 25807101.
  30. ^ SCALA, E; PALLOTTA, S; FREZZOLINI, A; ABENI, D; BARBIERI, C; SAMPOGNA, F; DE PITÀ, O; PUDDU, P; PAGANELLI, R; RUSSO, G (December 31, 2004). "Cytokine and chemokine levels in systemic sclerosis: relationship with cutaneous and internal organ involvement". Clinical and Experimental Immunology. 138 (3): 540–546. doi:10.1111/j.1365-2249.2004.02642.x. PMC 1809238. PMID 15544634.
  31. ^ R, Paganelli; E, Scala; R, Rosso; A, Cossarizza; L, Bertollo; D, Barbieri; A, Fabrizi; Ea, Lusi; U, Fagiolo; C, Franceschi (September 30, 1996). "A shift to Th0 cytokine production by CD4+ cells in human longevity: studies on two healthy centenarians". European Journal of Immunology. 26 (9): 2030–2034. doi:10.1002/eji.1830260910. PMID 8814242. S2CID 34233284.
  32. ^ Gp, Bagnara; L, Bonsi; P, Strippoli; F, Bonifazi; R, Tonelli; S, D'Addato; R, Paganelli; E, Scala; U, Fagiolo; D, Monti; A, Cossarizza; M, Bonafé; C, Franceschi (February 29, 2000). "Hemopoiesis in healthy old people and centenarians: well-maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network". The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 55 (2): B61–B66. doi:10.1093/gerona/55.2.b61. hdl:11380/1287719. PMID 10737681.
  33. ^ Di Iorio, Angelo; Ferrucci, Luigi; Sparvieri, Eleonora; Cherubini, Antonio; Volpato, Stefano; Corsi, Annamaria; Bonafè, Massimo; Franceschi, Claudio; Abate, Giuseppe; Paganelli, Roberto (June 21, 2003). "Serum IL-1beta levels in health and disease: a population-based study. 'The InCHIANTI study'". Cytokine. 22 (6): 198–205. doi:10.1016/s1043-4666(03)00152-2. PMID 12890453.
  34. ^ Paganelli, Alessia; Garbarino, Federico; Toto, Paola; Martino, Giuseppe Di; D'Urbano, Marika; Auriemma, Matteo; Giovanni, Pamela Di; Panarese, Fabrizio; Staniscia, Tommaso; Amerio, Paolo; Paganelli, Roberto (August 31, 2019). "Serological landscape of cytokines in cutaneous melanoma". Cancer Biomarkers: Section a of Disease Markers. 26 (3): 333–342. doi:10.3233/CBM-190370. PMID 31561328. S2CID 203579946.
  35. ^ Paganelli, Roberto; Paganelli, Alessia; Pawelec, Graham; Di Iorio, Angelo (March 11, 2023). "Natural IgG antibodies to β amyloid are decreased in patients with Parkinson's disease". Immunity & Ageing. 20 (1): 13. doi:10.1186/s12979-023-00336-w. PMC 10007830. PMID 36906630.
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