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Robert W. Malone

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For other people with the same name, see Robert Malone.

Robert W. Malone
Born
Robert Wallace Malone

(1959-10-20) October 20, 1959 (age 65)[1][2]
EducationUniversity of California, Davis (BS)
University of California, San Diego (MS)
Northwestern University (MD)
Occupation(s)Physician, biochemist
Websiterwmalonemd.com

Robert Wallace Malone (born October 20, 1959) is an American physician and biochemist. His early work focused on mRNA technology,[3] pharmaceuticals, and drug repurposing research. During the COVID-19 pandemic, Malone promoted misinformation about the safety and efficacy of COVID-19 vaccines.[1][4][5][6][7]

Early life and education

Prior to studying medicine, Robert Malone studied computer science at Santa Barbara City College for two years, acting as a teaching assistant in 1981.[2][8] He received his BS in biochemistry from the University of California, Davis in 1984, his MS in biology from the University of California, San Diego in 1988, and his MD from Northwestern University Feinberg School of Medicine in 1991.[9][10][11] He attended Harvard Medical School for a year-long postdoctoral studies program.[12]

In the decade after earning his MD, Malone taught pathology at the University of California, Davis and at the University of Maryland.[7]

Career

In the late 1980s, while a graduate student researcher at the Salk Institute for Biological Studies in San Diego, California, Malone conducted studies on messenger ribonucleic acid (mRNA) technology, discovering in what Nature has described as a landmark experiment that it was possible to transfer mRNA protected by a liposome into cultured cells to signal the information needed for the production of proteins.[3][13][4] With Philip Felgner, he performed experiments on the transfection of RNA into human, rat, mouse, Xenopus, and Drosophila cells, work which was published in 1989.[3][14] In 1990, he contributed to a paper with Jon A. Wolff, Dennis A. Carson, and others, which first suggested the possibility of synthesizing mRNA in a laboratory to trigger the production of a desired protein.[15] These studies are recognized as among the earliest steps towards mRNA vaccine development.[3][16][17][18]

While Malone promotes himself as an inventor of mRNA vaccines,[1][7] credit for the distinction is more often given to the lead authors on the major papers he contributed to (such as Felgner and Wolff), later advances by Katalin Karikó and Drew Weissman,[3][19] or Moderna co-founder Derrick Rossi.[13] Ultimately, mRNA vaccines were the decades-long result of the contributions of hundreds of researchers, including Malone.[3][20][21] In April 2022, Davey Alba, writing for The New York Times, said that "[w]hile he was involved in some early research into the technology, his role in its creation was minimal at best", citing "half a dozen Covid experts and researchers, including three who worked closely with Dr. Malone."[7]

Malone has served as director of clinical affairs for Avancer Group, assistant professor at the University of Maryland School of Medicine, and an adjunct associate professor of biotechnology at Kennesaw State University.[22] He was CEO and co-founder of Atheric Pharmaceutical,[23] which in 2016 was contracted by the U.S. Army Medical Research Institute of Infectious Diseases to assist in the development of a treatment for the Zika virus by evaluating the efficacy of existing drugs.[24][25][26][27] Until 2020, Malone was chief medical officer at Alchem Laboratories, a Florida pharmaceutical company.[28] He has claimed he helped secure early-stage approval for research by Merck & Co. on an Ebola vaccine, in the mid-2010s.[7]

COVID-19 research and controversy

In early 2020, during the COVID-19 pandemic, Malone was involved in research through the Defense Threat Reduction Agency's DOMANE program into the heartburn medicine famotidine (Pepcid) as a potential COVID-19 treatment.[29] His interest in the drug candidate followed early observational data suggesting that it may have been associated with higher COVID-19 survival.[30] Malone, then with Alchem Laboratories, suspected famotidine may target an enzyme that the virus (SARS-CoV-2) uses to reproduce, and recruited a computational chemist to help design a 3D-model of the enzyme based on the viral sequence and comparisons to the 2003 SARS virus.[29] After encouraging preliminary results, Alchem Laboratories, in conjunction with New York's Northwell Health, initiated a clinical trial on famotidine and hydroxychloroquine.[29] Malone resigned from Alchem shortly after the trial began and Northwell paused the trial due to a shortage of hospitalized patients.[28][31]

With another researcher, Malone successfully proposed to the publishers of Frontiers in Pharmacology a special issue featuring early observational studies on existing medication used in the treatment of COVID-19, for which they recruited other guest editors, contributors, and reviewers. The journal rejected two of the papers selected: one on famotidine co-authored by Malone and another submitted by physician Pierre Kory on the use of ivermectin.[31] The publisher rejected the ivermectin paper due to what it stated were "a series of strong, unsupported claims" which they determined did "not offer an objective nor balanced scientific contribution."[31] Malone and most other guest editors resigned in protest in April 2021, and the special issue has been pulled from the journal's website.[31]

Starting in mid-2021, Malone received criticism for propagating COVID-19 misinformation and conspiracy theories, including making "dangerous" and misleading claims about the toxicity of spike proteins generated by some COVID-19 vaccines;[4][32][6][33] using interviews on mass media to popularize medication with ivermectin;[34] and tweeting a study by others questioning vaccine safety that was later retracted.[4] He said that LinkedIn temporarily suspended his account over a post stating that the Chairman of the Thomson Reuters Foundation was also a board member at Pfizer, and other posts questioning the efficacy of some COVID-19 vaccines.[35][36] Malone has also falsely claimed that the Pfizer–BioNTech and Moderna COVID-19 vaccines could worsen COVID-19 infections,[1] and that the Food and Drug Administration (FDA) had not granted full approval to the Pfizer vaccine in August 2021.[37] Malone has promoted hydroxychloroquine and ivermectin as COVID-19 treatments.[7] In a July 2021 interview, Malone admitted to taking the Moderna vaccine, claiming that he did so due to suffering from long COVID, and because he and his wife needed to travel.[20]

In November 2021, Malone shared a deceptive video on Twitter that falsely linked athlete deaths to COVID-19 vaccines. In particular, the video suggested that Jake West, a 17-year-old Indiana high school football player who succumbed to sudden cardiac arrest, had actually died from COVID-19 vaccination. However, West had died years earlier, in 2013, due to an undiagnosed heart condition. Malone deleted the video from his Twitter account after receiving a cease-and-desist letter from West's family. Malone later said on Twitter that he did not know the video was doctored.[38] On December 29, 2021, Twitter permanently suspended Malone from its platform, citing "repeated violations of our COVID-19 misinformation policy",[39][40] after he shared on that platform a video about supposed harmful effects of the Pfizer vaccine.[41][42] In an April 1, 2022 interview, Malone made the unfounded claim that COVID-19 vaccines are "damaging T cell responses" and "causing a form of AIDS". Malone claimed that he had "lots of scientific data" to back up his claim, but did not cite evidence.[43] In July 2022, Malone, along with two other doctors, filed a lawsuit against Twitter for suspending their accounts, alleging a "breach of contract."[44]

On December 30, 2021, Malone claimed on The Joe Rogan Experience podcast that "mass formation psychosis" was developing in American society in its reaction to COVID-19 just as during the rise of Nazi Germany.[45][46] The term mass formation psychosis is not found in the Diagnostic and Statistical Manual of Mental Disorders, is not based on factual medical information, and is described by Steve Reicher, a professor of social psychology at the University of St Andrews, as "more metaphor than science, more ideology than fact."[47] 270 physicians, scientists, academics, nurses and students wrote an open letter to Spotify complaining about the content of the podcast.[48][49] On January 3, 2022, Congressman Troy Nehls entered a full transcript[2][50] of The Joe Rogan Experience interview with Malone into the Congressional Record in order to circumvent what he said was censorship by social media.[2][45]

Malone has spoken at anti-vaccine and anti-vaccine-mandate rallies, including a January 2022 rally in front of the Lincoln Memorial in Washington, D.C.,[38][51] and a March 2022 rally in Santa Barbara, California.[52] As of April 2022, more than 134,000 users subscribe to Malone's Substack newsletter.[7] According to media research firm Zignal Labs, Malone has been mentioned more than 300,000 times on social media, cable television, and print or online news outlets.[7] In December 2022, Malone was reinstated on Twitter as a result of Elon Musk's revision of the site's COVID disinformation policy.[53][54]

Personal life and politics

Malone lives in Madison, Virginia, on a horse farm with his wife Jill Glasspool Malone, his high school sweetheart whom he married c. 1979.[55] [56][57] She has a PhD in public policy from Union Institute and University.[1][7][58] Although he and his wife have attended several conservative conferences, Malone says that he does not align with any political party.[7]

References

  1. ^ a b c d e Bartlett, Tom (August 12, 2021). "The Vaccine Scientist Spreading Vaccine Misinformation". The Atlantic. Archived from the original on February 4, 2022. Retrieved January 3, 2022.
  2. ^ a b c d "Joe Rogan Experience #1757 – Dr. Robert Malone, MD Full Transcript". Congressman Troy Nehls. January 3, 2022. Archived from the original on January 14, 2022. Retrieved January 6, 2022.
  3. ^ a b c d e f Dolgin, Elie (September 14, 2021). "The tangled history of mRNA vaccines". Nature. 597 (7876): 318–324. Bibcode:2021Natur.597..318D. doi:10.1038/d41586-021-02483-w. PMID 34522017. S2CID 237515383. Archived from the original on December 27, 2021. Retrieved December 26, 2021.
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  8. ^ "Exhibit F - Declaration of Dr. Robert Malone – #30, Att. #6 in Navy Seal 1 v. Austin (M.D. Fla., 8:21-cv-02429) – CourtListener.com". CourtListener. Archived from the original on March 20, 2022. Retrieved March 20, 2022.
  9. ^ "License Number: D55466 Dr. Robert Wallace Malone". Physician Profile Portal. Maryland Board of Physicians. Archived from the original on February 4, 2022. Retrieved January 2, 2022.
  10. ^ Malone, Robert. "Robert Malone". LinkedIn.com. Robert W. Malone. Archived from the original on September 3, 2010. Retrieved January 2, 2021.
  11. ^ One Hundred and Thirty-third Annual Commencement. Northwestern University. 1991. p. 13. Robert Wallace Malone, M.S., University of California, San Diego, 1988
  12. ^ Carr, Julie (December 18, 2021). "mRNA Vaccine Inventor Dr. Robert Malone to Hold Global COVID Summit on Saturday in Gallatin". The Tennessee Star. Archived from the original on January 2, 2022. Retrieved January 3, 2022.
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  14. ^ Robert Malone; Philip L. Felgner; Inder Verma (August 1, 1989). "Cationic liposome-mediated RNA transfection". Proceedings of the National Academy of Sciences of the United States of America. 86 (16): 6077–6081. Bibcode:1989PNAS...86.6077M. doi:10.1073/PNAS.86.16.6077. ISSN 0027-8424. PMC 297778. PMID 2762315. Wikidata Q34295651.
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  29. ^ a b c Borrell, Brendan (April 26, 2020). "New York clinical trial quietly tests heartburn remedy against coronavirus". Science. doi:10.1126/science.abc4739. S2CID 219040361.
  30. ^ Malone, Robert W.; Tisdall, Philip; Fremont-Smith, Philip; Liu, Yongfeng; Huang, Xi-Ping; White, Kris M.; Miorin, Lisa; Moreno, Elena; Alon, Assaf; Delaforge, Elise; Hennecker, Christopher D.; Wang, Guanyu; Pottel, Joshua; Blair, Robert V.; Roy, Chad J. (2021). "COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms". Frontiers in Pharmacology. 12: 633680. doi:10.3389/fphar.2021.633680. ISSN 1663-9812. PMC 8021898. PMID 33833683.
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  33. ^ "【誤導內容】Robert Malone是mRNA疫苗發明者？" [[Misleading content] Robert Malone is the inventor of the mRNA vaccine?]. factchecklab.org (in Chinese (Hong Kong)). Factcheck Lab 事實查核實驗室. August 28, 2021. Archived from the original on February 4, 2022. Retrieved October 18, 2021.
  34. ^ Karlis, Nicole (August 9, 2021). "How anti-vaxxers weaponized Ivermectin, a horse de-wormer drug, as a COVID-19 treatment". Salon.com. Archived from the original on August 10, 2021. Retrieved August 10, 2021.
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  39. ^ Goforth, Clare (January 1, 2022). "Conservatives think the U.S. is experiencing a 'mass formation psychosis' because an anti-vaxxer doctor told Joe Rogan so". The Daily Dot. Archived from the original on February 4, 2022.
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  50. ^ 2021 Congressional Record, Vol. 167, Page e1403 (January 3, 2022)
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  53. ^ Checknews, Service (December 14, 2022). "Qui est le controversé Dr Malone, pionnier de l'ARN messager, dont le compte Twitter vient d'être réactivé ?". Libération (in French). Archived from the original on December 14, 2022. Retrieved December 14, 2022.
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  55. ^ "Discover thousands of collaborative articles on 2500+ skills". www.linkedin.com. Archived from the original on January 1, 2023.
  56. ^ "Robert W Malone MD". Robert W Malone MD. Archived from the original on August 3, 2021.
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  58. ^ "The Malone Doctrine Health Conference Ireland". worldcouncilforhealth.org. World Council for Health. Archived from the original on December 19, 2022. Retrieved December 19, 2022.
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