Remeglurant

Remeglurant
Clinical data
Other names	MRZ-8456
ATC code	None;
Identifiers
	IUPAC name (6-Bromopyrazolo[1,5-a]pyrimidin-2-yl)[(1R)-1-methyl-3,4-dihydro-2(1H)-isoquinolinyl]methanone;
CAS Number	1309783-00-3;
PubChem CID	24810684;
ChemSpider	32701693;
UNII	Y7H8880HMD;
CompTox Dashboard (EPA)	DTXSID501032318 ;
Chemical and physical data
Formula	C17H15BrN4O
Molar mass	371.238 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1c2ccccc2CCN1C(=O)c3cc4ncc(cn4n3)Br;
	InChI InChI=1S/C17H15BrN4O/c1-11-14-5-3-2-4-12(14)6-7-21(11)17(23)15-8-16-19-9-13(18)10-22(16)20-15/h2-5,8-11H,6-7H2,1H3/t11-/m1/s1; Key:TUYZYSNXXSTKQX-LLVKDONJSA-N;

Remeglurant (INNTooltip International Nonproprietary Name; developmental code name MRZ-8456) is a drug which acts as a selective antagonist of the mGlu₅ receptor.^[1]^[2]^[3] It is under development by Merz Pharmaceuticals for the treatment of drug-induced dyskinesia but no development has been reported since at least 2016.^[3]

References

^ World Health Organization (2013). "International Nonproprietary Names for Pharmaceutical Substances (INN): Proposed INN: List 109" (PDF). WHO Drug Information. 27 (2). World Health Organization.
^ US 7985753, Danysz W, Dekundy A, Hechenberger M, Henrich M, Jatzke C, Nagel J, Parsons CG, Weil T, Fotins J, Gutcaits A, Kalvinsh I, Zemribo R, Kauss V, "Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators.", issued 4 August 2006, assigned to Merz Pharmaceuticals GmbH
^ ^a ^b "Remeglurant". Adis Insight. Springer Nature Switzerland AG.

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[WHO2013-1] World Health Organization (2013). "International Nonproprietary Names for Pharmaceutical Substances (INN): Proposed INN: List 109" (PDF). WHO Drug Information. 27 (2). World Health Organization.

[Danysz2006-2] US 7985753, Danysz W, Dekundy A, Hechenberger M, Henrich M, Jatzke C, Nagel J, Parsons CG, Weil T, Fotins J, Gutcaits A, Kalvinsh I, Zemribo R, Kauss V, "Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators.", issued 4 August 2006, assigned to Merz Pharmaceuticals GmbH

[AdisInsight-3] "Remeglurant". Adis Insight. Springer Nature Switzerland AG.

[1]

[2]

[3]

See also

References