Reticulon-1 also known as neuroendocrine-specific protein (NSP) is a protein that in humans is encoded by the RTN1gene.[5][6]
This gene belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kools PF, Roebroek AJ, Van de Velde HJ, Marynen P, Bullerdiek J, Van de Ven WJ (February 1994). "Regional mapping of the human NSP gene to chromosome region 14q21→q22 by fluorescence in situ hybridization analysis". Cytogenet Cell Genet. 66 (1): 48–50. doi:10.1159/000133662. PMID8275708.
Senden NH, van de Velde HJ, Broers JL, Timmer ED, Roebroek AJ, van de Ven WJ, Ramaekers FC (1994). "Cluster-10 lung-cancer antibodies recognize NSPs, novel neuro-endocrine proteins associated with membranes of the endoplasmic reticulum". Int. J. Cancer Suppl. 8: 84–8. doi:10.1002/ijc.2910570718. PMID7515034. S2CID22321780.
van de Velde HJ, Roebroek AJ, Senden NH, Ramaekers FC, Van de Ven WJ (1995). "NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum". J. Cell Sci. 107 (9): 2403–16. doi:10.1242/jcs.107.9.2403. PMID7844160.
van de Velde HJ, Senden NH, Roskams TA, Broers JL, Ramaekers FC, Roebroek AJ, Van de Ven WJ (1994). "NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis". Cancer Res. 54 (17): 4769–76. PMID8062278.
Roebroek AJ, Ayoubi TA, Van de Velde HJ, Schoenmakers EF, Pauli IG, Van de Ven WJ (1997). "Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons". Genomics. 32 (2): 191–9. doi:10.1006/geno.1996.0105. PMID8833145.
Senden NH, Timmer ED, Boers JE, van de Velde HJ, Roebroek AJ, Van de Ven WJ, Broers JL, Ramaekers FC (1996). "Neuroendocrine-specific protein C (NSP-C): subcellular localization and differential expression in relation to NSP-A". Eur. J. Cell Biol. 69 (3): 197–213. PMID8900485.
Hens J, Nuydens R, Geerts H, Senden NH, Van de Ven WJ, Roebroek AJ, van de Velde HJ, Ramaekers FC, Broers JL (1998). "Neuronal differentiation is accompanied by NSP-C expression". Cell Tissue Res. 292 (2): 229–37. doi:10.1007/s004410051054. PMID9560466. S2CID1743385.
Di Sano F, Fazi B, Citro G, Lovat PE, Cesareni G, Piacentini M (2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–5. PMID12873973.
Iwahashi J, Hamada N (2004). "Human reticulon 1-A and 1-B interact with a medium chain of the AP-2 adaptor complex". Cell. Mol. Biol. (Noisy-le-grand). 49 Online Pub: OL467–71. PMID14995077.
He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959–65. doi:10.1038/nm1088. PMID15286784. S2CID23570406.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID16189514. S2CID4427026.
Mannan AU, Boehm J, Sauter SM, Rauber A, Byrne PC, Neesen J, Engel W (2007). "Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein". Neurogenetics. 7 (2): 93–103. doi:10.1007/s10048-006-0034-4. PMID16602018. S2CID8509463.