From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Rab effector Noc2 is a protein that in humans is encoded by the RPH3AL gene .[ 5] [ 6]
RPH3AL has been shown to interact with RAB27A .[ 7] [ 8]
^ a b c ENSG00000262334, ENSG00000282013 GRCh38: Ensembl release 89: ENSG00000181031, ENSG00000262334, ENSG00000282013 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020847 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C (July 1999). "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus". Genomics . 59 (1): 97–101. doi :10.1006/geno.1999.5864 . PMID 10395805 . ^ "Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)" .^ Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R (January 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis" . Molecular Endocrinology . 18 (1): 117–26. doi :10.1210/me.2003-0300 PMID 14593078 . ^ Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2" . The Journal of Biological Chemistry . 278 (17): 15373–80. doi :10.1074/jbc.M212341200 PMID 12578829 .
Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S (November 1997). "Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells" . The Journal of Biological Chemistry . 272 (47): 29407–10. doi :10.1074/jbc.272.47.29407 PMID 9367993 . Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC (January 2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon" . Neuron . 25 (1): 203–14. doi :10.1016/S0896-6273(00)80883-1 PMID 10707984 . S2CID 10177138 . Haynes LP, Evans GJ, Morgan A, Burgoyne RD (March 2001). "A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells" . The Journal of Biological Chemistry . 276 (13): 9726–32. doi :10.1074/jbc.M006959200 PMID 11134008 . Goi T, Takeuchi K, Katayama K, Hirose K, Yamaguchi A (2003). "Mutations of rabphillin-3A-like gene in colorectal cancers". Oncology Reports . 9 (6): 1189–92. doi :10.3892/or.9.6.1189 . PMID 12375017 . Milkereit P, Strauss D, Bassler J, Gadal O, Kühn H, Schütz S, Gas N, Lechner J, Hurt E, Tschochner H (February 2003). "A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits" . The Journal of Biological Chemistry . 278 (6): 4072–81. doi :10.1074/jbc.M208898200 PMID 12446671 . Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2" . The Journal of Biological Chemistry . 278 (17): 15373–80. doi :10.1074/jbc.M212341200 PMID 12578829 . Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (April 2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3" . American Journal of Human Genetics . 72 (4): 918–30. doi :10.1086/374320 . PMC 1180354 PMID 12621583 . Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R (January 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis" . Molecular Endocrinology . 18 (1): 117–26. doi :10.1210/me.2003-0300 PMID 14593078 . Manabe S, Nishimura N, Yamamoto Y, Kitamura H, Morimoto S, Imai M, Nagahiro S, Seino S, Sasaki T (March 2004). "Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells". Biochemical and Biophysical Research Communications . 316 (1): 218–25. doi :10.1016/j.bbrc.2004.02.026 . PMID 15003533 . Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (June 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells" . Proceedings of the National Academy of Sciences of the United States of America . 101 (22): 8313–8. Bibcode :2004PNAS..101.8313M . doi :10.1073/pnas.0306709101 PMC 420391 PMID 15159548 . Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U (January 2008). "Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma" . Frontiers in Bioscience . 13 (1): 1050–61. doi :10.2741/2742 . PMC 2667692 PMID 17981610 .
