RIC3

RIC3
Identifiers
Aliases	RIC3, AYST720, PRO1385, RIC3 acetylcholine receptor chaperone, RIC-3
External IDs	OMIM: 610509; MGI: 2443887; HomoloGene: 49772; GeneCards: RIC3; OMA:RIC3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	8,169,055 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	108,682,538 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; right hemisphere of cerebellum; ; body of pancreas; ; right uterine tube; ; left ovary; ; gastric mucosa; ; skin of abdomen; ; minor salivary glands;
	Top expressed in
	Rostral migratory stream; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; visual cortex; ; primary visual cortex; ; lumbar subsegment of spinal cord; ; superior frontal gyrus; ; spermatocyte; ; cerebellar cortex; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein folding chaperone activity; acetylcholine receptor binding;
Cellular component	integral component of membrane; neuron projection; Golgi membrane; soma; Golgi apparatus; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; membrane;
Biological process	positive regulation of cytosolic calcium ion concentration; synaptic transmission, cholinergic; protein localization to cell surface; protein folding;
	Sources:Amigo / QuickGO
Orthologs
	79608
	320360
	ENSG00000166405
	ENSMUSG00000048330
	Q7Z5B4
	Q8BPM6
NM_001135109; NM_001206671; NM_001206672; NM_024557; NM_001346690;
	NM_001346691; NM_001346692; NM_001346693; NM_001346694
	NM_001038624; NM_178780; NM_001311161
NP_001128581; NP_001193600; NP_001193601; NP_001333619; NP_001333620;
	NP_001333621; NP_001333622; NP_001333623; NP_078833
	NP_001033713; NP_001298090; NP_848895
	Wikidata
View/Edit Human	View/Edit Mouse

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans.^[5] RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT₃ receptor and nicotinic acetylcholine receptors,^[6]^[7] particularly the homomeric α₇ nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048330 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nguyen M, Alfonso A, Johnson CD, Rand JB (Jun 1995). "Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase". Genetics. 140 (2): 527–35. doi:10.1093/genetics/140.2.527. PMC 1206632. PMID 7498734.
^ Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M (Sep 2003). "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression". J Biol Chem. 278 (36): 34411–7. doi:10.1074/jbc.M300170200. hdl:10261/289220. PMID 12821669.
^ "Entrez Gene: RIC3 resistance to inhibitors of cholinesterase 3 homolog (C. elegans)".
^ Williams ME, Burton B, Urrutia A, et al. (2005). "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells". J. Biol. Chem. 280 (2): 1257–63. doi:10.1074/jbc.M410039200. PMID 15504725.

Cheng A, Bollan KA, Greenwood SM, et al. (2007). "Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition". J. Biol. Chem. 282 (36): 26158–66. doi:10.1074/jbc.M703899200. PMID 17609200.
Castillo M, Mulet J, Gutiérrez LM, et al. (2007). "Role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors". J. Mol. Neurosci. 30 (1–2): 153–6. doi:10.1385/JMN:30:1:153. PMID 17192664. S2CID 41109579.
Lansdell SJ, Gee VJ, Harkness PC, et al. (2005). "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells". Mol. Pharmacol. 68 (5): 1431–8. doi:10.1124/mol.105.017459. PMID 16120769. S2CID 12901942.
Castillo M, Mulet J, Gutiérrez LM, et al. (2005). "Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors". J. Biol. Chem. 280 (29): 27062–8. doi:10.1074/jbc.M503746200. hdl:10261/307538. PMID 15927954.
Cheng A, McDonald NA, Connolly CN (2005). "Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3". J. Biol. Chem. 280 (23): 22502–7. doi:10.1074/jbc.M414341200. PMID 15809299.
Bennett HM, Lees K, et al. (2012). "Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes". J. Neurochem. 123 (6): 911–8. doi:10.1111/jnc.12013. PMC 3549563. PMID 22970690.
Koperniak TM, Garg BK, et al. (2013). "Cell-specific effects on surface α7 nicotinic receptor expression revealed by over-expression and knockdown of rat RIC3 protein". J. Neurochem. 124 (3): 300–9. doi:10.1111/jnc.12095. PMID 23157401. S2CID 12489865.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166405 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048330 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7498734-5] Nguyen M, Alfonso A, Johnson CD, Rand JB (Jun 1995). "Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase". Genetics. 140 (2): 527–35. doi:10.1093/genetics/140.2.527. PMC 1206632. PMID 7498734.

[pmid12821669-6] Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M (Sep 2003). "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression". J Biol Chem. 278 (36): 34411–7. doi:10.1074/jbc.M300170200. hdl:10261/289220. PMID 12821669.

[entrez-7] "Entrez Gene: RIC3 resistance to inhibitors of cholinesterase 3 homolog (C. elegans)".

[pmid15504725-8] Williams ME, Burton B, Urrutia A, et al. (2005). "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells". J. Biol. Chem. 280 (2): 1257–63. doi:10.1074/jbc.M410039200. PMID 15504725.

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References

Further reading