RGS11

RGS11
Identifiers
Aliases	RGS11, RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11
External IDs	OMIM: 603895; MGI: 1354739; HomoloGene: 77719; GeneCards: RGS11; OMA:RGS11 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	275,980 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,430,298 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; anterior pituitary; ; C1 segment; ; cingulate gyrus; ; anterior cingulate cortex; ; tibial nerve; ; amygdala; ; Brodmann area 9; ; apex of heart;
	Top expressed in
	neural layer of retina; ; superior frontal gyrus; ; morula; ; primary visual cortex; ; islet of Langerhans; ; adrenal gland; ; ganglion of vagus nerve; ; autonomic nerve plexus; ; CA3 field; ; stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G-protein beta-subunit binding; GTPase activator activity; GTPase activity;
Cellular component	cytoplasm; plasma membrane; protein-containing complex; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; negative regulation of signal transduction; intracellular signal transduction; regulation of G protein-coupled receptor signaling pathway; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	8786
	50782
	ENSG00000076344
	ENSMUSG00000024186
	O94810
	Q9Z2H1
	NM_001286485; NM_001286486; NM_003834; NM_183337
	NM_001081069
	NP_001273414; NP_001273415; NP_003825; NP_899180
	NP_001074538
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.^[5]^[6]

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076344 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024186 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
^ ^a ^b "Entrez Gene: RGS11 regulator of G-protein signalling 11".

Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" (PDF). Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553. S2CID 4362044.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488. S2CID 16065132.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. Bibcode:1999PNAS...96.6489S. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain". J. Neurosci. 17 (20): 8024–37. doi:10.1523/JNEUROSCI.17-20-08024.1997. PMC 6793903. PMID 9315921.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076344 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024186 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9789084-5] Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.

[entrez-6] "Entrez Gene: RGS11 regulator of G-protein signalling 11".

[1]

[2]

[3]

[4]

[5]

[6]

References

Further reading