RAB9A

RAB9A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WMS
Identifiers
Aliases	RAB9A, RAB9, member RAS oncogene family
External IDs	OMIM: 300284; MGI: 1890695; HomoloGene: 20900; GeneCards: RAB9A; OMA:RAB9A - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp22.2 Start 13,689,128 bp End 13,710,504 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F5 Start 165,240,249 bp End 165,262,863 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid parotid gland palpebral conjunctiva corpus callosum right adrenal cortex skin of hip epithelium of nasopharynx left adrenal gland skin of thigh left adrenal cortex Top expressed in trigeminal ganglion mucous cell of stomach epithelium of small intestine medial ganglionic eminence left lobe of liver epithelium of stomach brown adipose tissue calvaria genital tubercle left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding protein binding GTPase activity identical protein binding Cellular component endosome late endosome phagocytic vesicle membrane Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane plasma membrane phagocytic vesicle endoplasmic reticulum lysosome extracellular exosome cytoplasmic vesicle cytoplasmic vesicle membrane trans-Golgi network membrane cytosol transport vesicle melanosome Biological process regulation of protein localization retrograde transport, endosome to Golgi protein transport positive regulation of exocytosis transport intracellular protein transport Rab protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9367 56382 Ensembl ENSG00000123595 ENSMUSG00000079316 UniProt P51151 Q9R0M6 RefSeq (mRNA) NM_004251 NM_001195328 NM_019773 RefSeq (protein) NP_001182257 NP_004242 NP_062747 Location (UCSC) Chr X: 13.69 – 13.71 Mb Chr X: 165.24 – 165.26 Mb PubMed search
Wikidata
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Ras-related protein Rab-9A is a protein that in humans is encoded by the RAB9A gene.

Interactions

RAB9A has been shown to interact with RABEPK, TIP47 and the Biogenesis of lysosome-related organelles complex 3.

Further reading

• Shapiro AD, Pfeffer SR (1995). "Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotides". J. Biol. Chem. 270 (19): 11085–90. doi:10.1074/jbc.270.19.11085. PMID 7744738.
• Soldati T, Riederer MA, Pfeffer SR (1993). "Rab GDI: a solubilizing and recycling factor for rab9 protein". Mol. Biol. Cell. 4 (4): 425–34. doi:10.1091/mbc.4.4.425. PMC 300943. PMID 8389620.
• Díaz E, Schimmöller F, Pfeffer SR (1997). "A novel Rab9 effector required for endosome-to-TGN transport". J. Cell Biol. 138 (2): 283–90. doi:10.1083/jcb.138.2.283. PMC 2138197. PMID 9230071.
• de Leeuw HP, Koster PM, Calafat J, Janssen H, van Zonneveld AJ, van Mourik JA, Voorberg J (1998). "Small GTP-binding proteins in human endothelial cells". Br. J. Haematol. 103 (1): 15–9. doi:10.1046/j.1365-2141.1998.00965.x. PMID 9792283. S2CID 24857520.
• Shisheva A, Chinni SR, DeMarco C (1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications". Biochemistry. 38 (36): 11711–21. doi:10.1021/bi990200r. PMID 10512627.
• Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR (2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47". Science. 292 (5520): 1373–6. Bibcode:2001Sci...292.1373C. doi:10.1126/science.1056791. PMID 11359012. S2CID 31343936.
• Orzaez D, de Jong AJ, Woltering EJ (2001). "A tomato homologue of the human protein PIRIN is induced during programmed cell death". Plant Mol. Biol. 46 (4): 459–68. doi:10.1023/A:1010618515051. PMID 11485202. S2CID 8587440.
• Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U, Müller CW (2002). "Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family". EMBO J. 20 (22): 6180–90. doi:10.1093/emboj/20.22.6180. PMC 125740. PMID 11707390.
• Barbero P, Bittova L, Pfeffer SR (2002). "Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells". J. Cell Biol. 156 (3): 511–8. doi:10.1083/jcb.200109030. PMC 2173336. PMID 11827983.
• Hanna J, Carroll K, Pfeffer SR (2002). "Identification of residues in TIP47 essential for Rab9 binding". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7450–4. Bibcode:2002PNAS...99.7450H. doi:10.1073/pnas.112198799. PMC 124251. PMID 12032303.
• Walter M, Davies JP, Ioannou YA (2004). "Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes". J. Lipid Res. 44 (2): 243–53. doi:10.1194/jlr.M200230-JLR200. PMID 12576506.
• Seaman MN (2004). "Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer". J. Cell Biol. 165 (1): 111–22. doi:10.1083/jcb.200312034. PMC 2172078. PMID 15078902.
• Chen L, DiGiammarino E, Zhou XE, Wang Y, Toh D, Hodge TW, Meehan EJ (2004). "High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target". J. Biol. Chem. 279 (38): 40204–8. doi:10.1074/jbc.M407114200. PMID 15263003.
• Ganley IG, Carroll K, Bittova L, Pfeffer S (2005). "Rab9 GTPase regulates late endosome size and requires effector interaction for its stability". Mol. Biol. Cell. 15 (12): 5420–30. doi:10.1091/mbc.E04-08-0747. PMC 532021. PMID 15456905.
• Ganley IG, Pfeffer SR (2006). "Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells". J. Biol. Chem. 281 (26): 17890–9. doi:10.1074/jbc.M601679200. PMC 3650718. PMID 16644737.
• Aivazian D, Serrano RL, Pfeffer S (2006). "TIP47 is a key effector for Rab9 localization". J. Cell Biol. 173 (6): 917–26. doi:10.1083/jcb.200510010. PMC 2063917. PMID 16769818.