RAB1A

RAB1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FOL, 2WWX, 3L0I, 3SFV, 3TKL, 4FMB, 4FMC, 4FMD, 4FME, 4IRU, 4JVS
Identifiers
Aliases	RAB1A, RAB1, YPT1, member RAS oncogene family
External IDs	OMIM: 179508; MGI: 97842; HomoloGene: 36154; GeneCards: RAB1A; OMA:RAB1A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	65,130,331 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	20,176,856 bp
RNA expression pattern
	Top expressed in
	sperm; ; skin of thigh; ; skin of hip; ; mucosa of sigmoid colon; ; corpus epididymis; ; jejunal mucosa; ; amniotic fluid; ; caput epididymis; ; tibia; ; oral cavity;
	Top expressed in
	calvaria; ; medial ganglionic eminence; ; seminal vesicula; ; stroma of bone marrow; ; sexually immature organism; ; molar; ; urothelium; ; transitional epithelium of urinary bladder; ; endothelial cell of lymphatic vessel; ; parotid gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; cadherin binding; GTPase activity;
Cellular component	cytoplasm; cytosol; endosome; Golgi apparatus; endoplasmic reticulum membrane; membrane; melanosome; Golgi membrane; early endosome; endoplasmic reticulum; extracellular exosome; transport vesicle membrane;
Biological process	COPII-coated vesicle cargo loading; endocytosis; establishment of endothelial intestinal barrier; Golgi organization; vesicle transport along microtubule; autophagosome assembly; positive regulation of glycoprotein metabolic process; autophagy; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII vesicle coating; melanosome transport; growth hormone secretion; defense response to bacterium; protein transport; substrate adhesion-dependent cell spreading; cell migration; vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; cilium assembly; positive regulation of ubiquitin protein ligase activity; post-translational protein modification; transport; intracellular protein transport; Rab protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5861
	19324
	ENSG00000138069
	ENSMUSG00000020149
	P62820
	P62821
	NM_004161; NM_015543
	NM_008996
	NP_004152; NP_056358
	NP_033022
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-1A is a protein that in humans is encoded by the RAB1A gene.^[5]^[6]

Interactions

RAB1A has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138069 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020149 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zahraoui A, Touchot N, Chardin P, Tavitian A (Jul 1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". The Journal of Biological Chemistry. 264 (21): 12394–401. doi:10.1016/S0021-9258(18)63872-4. PMID 2501306.
^ "Entrez Gene: RAB1A RAB1A, member RAS oncogene family".
^ ^a ^b Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (Jan 1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene". The Journal of Biological Chemistry. 269 (3): 2111–7. doi:10.1016/S0021-9258(17)42142-9. PMID 8294464.
^ Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC (Sep 1998). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex". Biochemistry. 37 (36): 12559–68. doi:10.1021/bi980881a. PMID 9730828.
^ ^a ^b Weide T, Teuber J, Bayer M, Barnekow A (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochemical and Biophysical Research Communications. 306 (1): 79–86. doi:10.1016/s0006-291x(03)00918-5. PMID 12788069.
^ Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters. 508 (2): 201–9. doi:10.1016/s0014-5793(01)02993-3. PMID 11718716. S2CID 21545088.
^ Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA (Dec 2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". The Journal of Cell Biology. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401.
^ Satoh A, Wang Y, Malsam J, Beard MB, Warren G (Mar 2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure". Traffic. 4 (3): 153–61. doi:10.1034/j.1600-0854.2003.00103.x. PMC 3282115. PMID 12656988.
^ Diao A, Rahman D, Pappin DJ, Lucocq J, Lowe M (Jan 2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation". The Journal of Cell Biology. 160 (2): 201–12. doi:10.1083/jcb.200207045. PMC 2172652. PMID 12538640.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. PMID 9341137.

Bailly E, McCaffrey M, Touchot N, Zahraoui A, Goud B, Bornens M (Apr 1991). "Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2". Nature. 350 (6320): 715–8. Bibcode:1991Natur.350..715B. doi:10.1038/350715a0. PMID 1902553. S2CID 4261640.
Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA (Dec 1994). "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 11963–7. Bibcode:1994PNAS...9111963F. doi:10.1073/pnas.91.25.11963. PMC 45356. PMID 7991565.
Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (Jan 1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene". The Journal of Biological Chemistry. 269 (3): 2111–7. doi:10.1016/S0021-9258(17)42142-9. PMID 8294464.
Karniguian A, Zahraoui A, Tavitian A (Aug 1993). "Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins". Proceedings of the National Academy of Sciences of the United States of America. 90 (16): 7647–51. Bibcode:1993PNAS...90.7647K. doi:10.1073/pnas.90.16.7647. PMC 47199. PMID 8356066.
Wedemeyer N, Lengeling A, Ronsiek M, Korthaus D, Baer K, Wuttke M, Jockusch H (Mar 1996). "YAC contigs of the Rab1 and wobbler (wr) spinal muscular atrophy gene region on proximal mouse chromosome 11 and of the homologous region on human chromosome 2p" (PDF). Genomics. 32 (3): 447–54. doi:10.1006/geno.1996.0140. hdl:20.500.11820/6e903f39-f1ac-4e99-a012-fd2195f13e44. PMID 8838809.
Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. PMID 9341137.
Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC (Sep 1998). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex". Biochemistry. 37 (36): 12559–68. doi:10.1021/bi980881a. PMID 9730828.
Bao S, Zhu J, Garvey WT (Nov 1998). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Hormone and Metabolic Research. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381. S2CID 23540699.
Allan BB, Moyer BD, Balch WE (Jul 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. Bibcode:2000Sci...289..444A. doi:10.1126/science.289.5478.444. PMID 10903204.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Moyer BD, Allan BB, Balch WE (Apr 2001). "Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering". Traffic. 2 (4): 268–76. doi:10.1034/j.1600-0854.2001.1o007.x. PMID 11285137. S2CID 43069518.
Muslin AJ (Dec 2001). "Road Rage: Cardiac Rab1 and ER-to-Golgi Traffic". Circulation Research. 89 (12): 1087–8. doi:10.1161/res.89.12.1087. PMID 11739271.
Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA (Dec 2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". The Journal of Cell Biology. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401.
Diao A, Rahman D, Pappin DJ, Lucocq J, Lowe M (Jan 2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation". The Journal of Cell Biology. 160 (2): 201–12. doi:10.1083/jcb.200207045. PMC 2172652. PMID 12538640.
Satoh A, Wang Y, Malsam J, Beard MB, Warren G (Mar 2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure". Traffic. 4 (3): 153–61. doi:10.1034/j.1600-0854.2003.00103.x. PMC 3282115. PMID 12656988.
Weide T, Teuber J, Bayer M, Barnekow A (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochemical and Biophysical Research Communications. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. PMID 12788069.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138069 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020149 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2501306-5] Zahraoui A, Touchot N, Chardin P, Tavitian A (Jul 1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". The Journal of Biological Chemistry. 264 (21): 12394–401. doi:10.1016/S0021-9258(18)63872-4. PMID 2501306.

[entrez-6] "Entrez Gene: RAB1A RAB1A, member RAS oncogene family".

[pmid8294464-7] Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (Jan 1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene". The Journal of Biological Chemistry. 269 (3): 2111–7. doi:10.1016/S0021-9258(17)42142-9. PMID 8294464.

[pmid9730828-8] Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC (Sep 1998). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex". Biochemistry. 37 (36): 12559–68. doi:10.1021/bi980881a. PMID 9730828.

[pmid12788069-9] Weide T, Teuber J, Bayer M, Barnekow A (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochemical and Biophysical Research Communications. 306 (1): 79–86. doi:10.1016/s0006-291x(03)00918-5. PMID 12788069.

[pmid11718716-10] Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters. 508 (2): 201–9. doi:10.1016/s0014-5793(01)02993-3. PMID 11718716. S2CID 21545088.

[pmid11739401-11] Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA (Dec 2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". The Journal of Cell Biology. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401.

[pmid12656988-12] Satoh A, Wang Y, Malsam J, Beard MB, Warren G (Mar 2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure". Traffic. 4 (3): 153–61. doi:10.1034/j.1600-0854.2003.00103.x. PMC 3282115. PMID 12656988.

[pmid12538640-13] Diao A, Rahman D, Pappin DJ, Lucocq J, Lowe M (Jan 2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation". The Journal of Cell Biology. 160 (2): 201–12. doi:10.1083/jcb.200207045. PMC 2172652. PMID 12538640.

[pmid16189514-14] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid9341137-15] Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. PMID 9341137.

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Interactions

References

Further reading