RAB15

RAB15
Identifiers
Aliases	RAB15, member RAS oncogene family
External IDs	MGI: 1916865; HomoloGene: 131279; GeneCards: RAB15; OMA:RAB15 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	64,973,226 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	76,869,682 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; endothelial cell; ; parotid gland; ; primary visual cortex;
	Top expressed in
	vestibular membrane of cochlear duct; ; transitional epithelium of urinary bladder; ; visual cortex; ; submandibular gland; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; lacrimal gland; ; olfactory tubercle; ; piriform cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; GTPase activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm; plasma membrane; endosome membrane; extracellular exosome; membrane; cilium; endosome; synaptic vesicle;
Biological process	protein transport; positive regulation of regulated secretory pathway; vesicle docking involved in exocytosis; protein secretion; transport; intracellular protein transport; regulation of exocytosis; Rab protein signal transduction; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	376267
	104886
	ENSG00000139998
	ENSMUSG00000021062
	P59190
	Q8K386
	NM_001308154; NM_198686; NM_001330182
	NM_134050; NM_001347405; NM_001347406; NM_001347407
	NP_001295083; NP_001317111; NP_941959
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-15 is a protein that in humans is encoded by the RAB15 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139998 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021062 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pereira-Leal JB, Seabra MC (Nov 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.
^ "Entrez Gene: RAB15 RAB15, member RAS onocogene family".

Zuk PA, Elferink LA (1999). "Rab15 mediates an early endocytic event in Chinese hamster ovary cells". J. Biol. Chem. 274 (32): 22303–12. doi:10.1074/jbc.274.32.22303. PMID 10428799.
Zuk PA, Elferink LA (2000). "Rab15 differentially regulates early endocytic trafficking". J. Biol. Chem. 275 (35): 26754–64. doi:10.1074/jbc.M000344200. PMID 10837464.
Strick DJ, Francescutti DM, Zhao Y, Elferink LA (2002). "Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis". J. Biol. Chem. 277 (36): 32722–9. doi:10.1074/jbc.M205101200. PMID 12105226.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strick DJ, Elferink LA (2006). "Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment". Mol. Biol. Cell. 16 (12): 5699–709. doi:10.1091/mbc.E05-03-0204. PMC 1289414. PMID 16195351.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139998 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021062 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11697911-5] Pereira-Leal JB, Seabra MC (Nov 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.

[entrez-6] "Entrez Gene: RAB15 RAB15, member RAS onocogene family".

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References

Further reading