queA RNA motif
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|
| queA | |
|---|---|
 Consensus secondary structure and sequence conservation of queA RNA | |
| Identifiers | |
| Symbol | queA |
| Rfam | RF03093 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
The queA RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] queA motif RNAs have not yet (as of 2018) been found in any classified organism; they are known from metagenomic sequences.
All known queA RNAs are located upstream of queA genes, which encodes an enzyme to alter the chemical structure of a specific nucleotide within tRNAs. It is possible that queA RNAs function as cis-regulatory elements. PreQ1 riboswitches are known that bind pre-queuosine1 and regulate genes that are related to queA. However, as the que RNA motif is not highly conserved and the queA gene itself is never known to be regulated by a preQ1 riboswitch, it is not likely that queA RNAs correspond to riboswitches.
References
[edit]- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.