Qatar Genome Programme
The Qatar Genome Programme aims to sequence the genomes of 350,000 inhabitants of Qatar.[1] Supported by the Sidra Medical and Research Center, the program is managed by Qatar Genome Committee and wants to eventually offer personalized healthcare in Qatar to its population with advances in genomics.[2] The Qatar Genome Programme published its first genome-wide association study with 45 clinically relevant traits in 2021 [3]
Apart from the Qatar Genome Programme, a number of other genome-scale studies have emerged from Qatar, including ones looking at the pharmacogenetic map[4] of Qatar from genome and exome sequences available in public domain. The availability of population-scale genomes from Qatar has also enabled the evaluation of Incidental genetic findings[5] which provides an estimate of the pathogenicity and frequency of such variants in the population, thereby forming the basis of genomic medicine in Qatar. Genetic epidemiological studies by integrating genomic data and variant annotations are also underway for autoinflammatory diseases[6]
The allele frequencies of population-scale genomes are also available[7]
See also
[edit]References
[edit]- ^ "WuXi NextCODE join Qatar Genome Project to power precision medicine development". Front Line Genomics.
- ^ "Qatar Biobank for Medical Research". www.qatarbiobank.org.qa.
- ^ Albagha, Thareja; Suhre, Al-Sarraj (2021). "Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits". Nature Communications. 12 (1): 1250. Bibcode:2021NatCo..12.1250T. doi:10.1038/s41467-021-21381-3. PMC 7902658. PMID 33623009.
- ^ Sivadas, Ambily; Scaria, Vinod (2018). "Pharmacogenomic survey of Qatari populations using whole-genome and exome sequences". The Pharmacogenomics Journal. 18 (4): 590–600. doi:10.1038/s41397-018-0022-8. PMID 29720721. S2CID 24137943.
- ^ Jain, Abhinav; Gandhi, Shrey; Koshy, Remya; Scaria, Vinod (August 2018). "Incidental and clinically actionable genetic variants in 1005 whole exomes and genomes from Qatar". Molecular Genetics and Genomics. 293 (4): 919–929. doi:10.1007/s00438-018-1431-8. ISSN 1617-4623. PMID 29557500. S2CID 3945453.
- ^ Sharma, Parul; Jain, Abhinav; Scaria, Vinod (2021). "Genetic landscape of rare autoinflammatory disease variants in Qatar and Middle Eastern populations through the integration of whole-genome and exome datasets". Frontiers in Genetics. 12: 631340. doi:10.3389/fgene.2021.631340. ISSN 1664-8021. PMC 8155677. PMID 34054914.
- ^ Koshy, Remya; Ranawat, Anop; Scaria, Vinod (October 2017). "al mena: a comprehensive resource of human genetic variants integrating genomes and exomes from Arab, Middle Eastern and North African populations". Journal of Human Genetics. 62 (10): 889–894. doi:10.1038/jhg.2017.67. ISSN 1435-232X. PMID 28638141. S2CID 36515834.