Prosultiamine

Prosultiamine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	None;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(1E)-4-hydroxy-1-methyl-2-(propyldisulfanyl)but-1-en-1-yl]formamide;
CAS Number	59-58-5;
PubChem CID	5355019;
ChemSpider	4511078;
UNII	UI32MM3XE3;
CompTox Dashboard (EPA)	DTXSID1046633 ;
ECHA InfoCard	100.000.397
Chemical and physical data
Formula	C15H24N4O2S2
Molar mass	356.50 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=CN(\C(=C(\SSCCC)CCO)C)Cc1cnc(nc1N)C;

Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B₁ deficiency.^[1]^[2] ^[3] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.^[4]^[5]

Research

It has been studied as a potential treatment for infection with human T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms.^[6]

References

^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
^ Triggle DJ (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.
^ Fujiwara M, Watanabe H, Matsui K (1954). ""allithiamine" A Newly Found Derivative of Vitamin B1". The Journal of Biochemistry. 41: 29–39. doi:10.1093/oxfordjournals.jbchem.a126421.
^ Thomson AD, Frank O, Baker H, Leevy CM (April 1971). "Thiamine propyl disulfide: absorption and utilization". Annals of Internal Medicine. 74 (4): 529–534. doi:10.7326/0003-4819-74-4-529. PMID 5551161.
^ Baker H, Frank O (August 1976). "Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines". Journal of Nutritional Science and Vitaminology. 22 SUPPL: 63–68. doi:10.3177/jnsv.22.supplement_63. PMID 978282.
^ "Nervous System Disease: A New Outlet for an Old Drug?". Science Daily. 15 August 2013.

[isbn3-88763-075-0-1] Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.

[isbn0-412-46630-9-2] Triggle DJ (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.

[3] Fujiwara M, Watanabe H, Matsui K (1954). ""allithiamine" A Newly Found Derivative of Vitamin B1". The Journal of Biochemistry. 41: 29–39. doi:10.1093/oxfordjournals.jbchem.a126421.

[pmid5551161-4] Thomson AD, Frank O, Baker H, Leevy CM (April 1971). "Thiamine propyl disulfide: absorption and utilization". Annals of Internal Medicine. 74 (4): 529–534. doi:10.7326/0003-4819-74-4-529. PMID 5551161.

[pmid978282-5] Baker H, Frank O (August 1976). "Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines". Journal of Nutritional Science and Vitaminology. 22 SUPPL: 63–68. doi:10.3177/jnsv.22.supplement_63. PMID 978282.

[6] "Nervous System Disease: A New Outlet for an Old Drug?". Science Daily. 15 August 2013.

[1]

[2]

[3]

[4]

[5]

[6]

Research

See also

References