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Procollagen C-endopeptidase

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Procollagen C-endopeptidase
Identifiers
EC no.3.4.24.19
CAS no.68651-95-6
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BRENDABRENDA entry
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MetaCycmetabolic pathway
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Procollagen C-endopeptidase (EC 3.4.24.19, procollagen C-terminal proteinase, carboxyprocollagen peptidase, procollagen C-terminal peptidase, procollagen C-proteinase, procollagen carboxypeptidase, procollagen carboxy-terminal proteinase, procollagen peptidase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III

This endopeptidase belongs to the peptidase family M12 (astacin family).

References

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  1. ^ Hojima Y, van der Rest M, Prockop DJ (December 1985). "Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization". The Journal of Biological Chemistry. 260 (29): 15996–6003. PMID 3905801.
  2. ^ Kessler E, Adar R (December 1989). "Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein". European Journal of Biochemistry. 186 (1–2): 115–21. doi:10.1111/j.1432-1033.1989.tb15184.x. PMID 2689170.
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