Precision cut kidney slices

Precision-cut kidney slices refer to thin sections of the kidney tissue that are prepared using a microtome to study kidney functions, drug metabolism or disease processes. Researchers use these slices to study the impact of substances on renal function.^[1]^[2] This includes drug metabolism^[3]^[4] and the effects of toxic substances.^[5]

References

^ Poosti, Fariba; Pham, Bao Tung; Oosterhuis, Dorenda; Poelstra, Klaas; van Goor, Harry; Olinga, Peter; Hillebrands, Jan-Luuk (2015-01-01). "Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo". Disease Models & Mechanisms. 8 (10): 1227–1236. doi:10.1242/dmm.020172. ISSN 1754-8411. PMC 4610232. PMID 26112172.
^ Genovese, Federica; Kàrpàti, Zsolt S.; Nielsen, Signe H.; Karsdal, Morten A. (2016). "Precision-Cut Kidney Slices as a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis". Biomarker Insights. 11: 77–84. doi:10.4137/BMI.S38439. PMC 4877083. PMID 27257368.
^ Graaf, Inge AM de; Groothuis, Geny MM; Olinga, Peter (2007). "Precision-cut tissue slices as a tool to predict metabolism of novel drugs". Expert Opinion on Drug Metabolism & Toxicology. 3 (6): 879–898. doi:10.1517/17425255.3.6.879. PMID 18028031. S2CID 36518505.
^ De Kanter, R.; Olinga, P.; De Jager, M.H; Merema, M.T; Meijer, D.K.F; Groothius, G.M.M (1999). "Organ Slices as an in Vitro Test System for Drug Metabolism in Human Liver, Lung and Kidney". Toxicology in Vitro. 13 (4–5): 737–744. doi:10.1016/S0887-2333(99)00047-8. PMID 20654543.
^ Parrish, Alan R.; Gandolfi, A.Jay; Brendel, Klaus (1995). "Precision-cut tissue slices: Applications in pharmacology and toxicology". Life Sciences. 57 (21): 1887–1901. doi:10.1016/0024-3205(95)02176-J. PMID 7475939.

[1] Poosti, Fariba; Pham, Bao Tung; Oosterhuis, Dorenda; Poelstra, Klaas; van Goor, Harry; Olinga, Peter; Hillebrands, Jan-Luuk (2015-01-01). "Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo". Disease Models & Mechanisms. 8 (10): 1227–1236. doi:10.1242/dmm.020172. ISSN 1754-8411. PMC 4610232. PMID 26112172.

[2] Genovese, Federica; Kàrpàti, Zsolt S.; Nielsen, Signe H.; Karsdal, Morten A. (2016). "Precision-Cut Kidney Slices as a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis". Biomarker Insights. 11: 77–84. doi:10.4137/BMI.S38439. PMC 4877083. PMID 27257368.

[3] Graaf, Inge AM de; Groothuis, Geny MM; Olinga, Peter (2007). "Precision-cut tissue slices as a tool to predict metabolism of novel drugs". Expert Opinion on Drug Metabolism & Toxicology. 3 (6): 879–898. doi:10.1517/17425255.3.6.879. PMID 18028031. S2CID 36518505.

[4] De Kanter, R.; Olinga, P.; De Jager, M.H; Merema, M.T; Meijer, D.K.F; Groothius, G.M.M (1999). "Organ Slices as an in Vitro Test System for Drug Metabolism in Human Liver, Lung and Kidney". Toxicology in Vitro. 13 (4–5): 737–744. doi:10.1016/S0887-2333(99)00047-8. PMID 20654543.

[5] Parrish, Alan R.; Gandolfi, A.Jay; Brendel, Klaus (1995). "Precision-cut tissue slices: Applications in pharmacology and toxicology". Life Sciences. 57 (21): 1887–1901. doi:10.1016/0024-3205(95)02176-J. PMID 7475939.

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