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Interstate 68 (I-68) is a 112.6-mile (181.2 km) Interstate highway in the U.S. states of West Virginia and Maryland, connecting Interstate 79 in Morgantown to Interstate 70 in Hancock. I-68 is also Corridor E of the Appalachian Development Highway System. From 1965 until the freeway's construction was completed in 1991, it was designated as U.S. Route 48 (US 48). In Maryland, the highway is known as the National Freeway', an homage to the historic National Road, which I-68 parallels between Keysers Ridge and Hancock. The freeway mainly spans rural areas, and crosses numerous mountain ridges along its route. A road cut constructed for it through Sideling Hill exposed geological features of the mountain and has become a tourist attraction.

There have been several major planned road projects that would affect the freeway's corridor, including a plan to extend I-68 to Moundsville, West Virginia (which, due to major funding issues, is unlikely to be completed As of  2010) and the plan to construct the Mon-Fayette Expressway, a toll highway which, when completed, will meet I-68 east of Morgantown.