- 2 – Dana International (1969), Israeli transgender pop singer
- 7 – Eddie Izzard (1962), English comic, actor and writer
- 17 – Harisu (1975), South Korean singer, model and actress
- 19 – Danielle Bunten Berry (1949-1998), American game designer and programmer
- 19 – Lea T (1981), Brazilian model
- 20 – Calpernia Addams (1971), American actress
- 20 – Tamara Adrián (1954), Venezuelan politician
- 21 – Michelle Suárez Bértora (1983), transgender Uruguayan politician
- 21 – Elliot Page (1987), Canadian actor
- 22 – Genesis P-Orridge (1950-2020), English third gender singer, songwriter, musician, performance artist
- 29 – Lena Raine (1984), American composer known for writing the Celeste, Deltarune, and other soundtracks.
- 4 – Chaz Bono (1969), American writer, musician and actor
- 10 – Janet Mock (1983), American trans woman, author, director and screenwriter
- 10 – Angela Morley (1924-2009), English musician and composer
- 13 – Joan Roughgarden (1946), American biologist
- 15 – Kate Bornstein (1948), American non-binary author and gender theorist
- 16 – Anna Grodzka (1954), Polish politician
- 18 – Charlotte von Mahlsdorf (1928-2002), German museum founder
- 28 – Alexandra Billings (1962), American transgender actress
- 7 – Karin Dreijer (1975), Swedish gender fluid singer-songwriter and record producer
- 8 – Roberta Cowell (1918–2011), British trans woman racing driver and fighter pilot
- 13 – Carmen Carrera (1985), American television personality, actress and model
- 18 – Audrey Tang (1981), Taiwanese programmer and government minister
- 20 – Gigi Gorgeous (1992), Canadian actress, YouTuber, model
- 23 – Geraldine Roman (1967), Filipino journalist and politician
- 28 – Leiomy Maldonado (1987), American dancer, instructor and model
- 29 – April Ashley (1935–2021), British model
- 1 – Christine and the Queens (1988), French non-binary singer and songwriter
- 3 – Daniela Vega (1989), Chilean transgender actress
- 5 – Buck Angel (1962), American adult film actor and producer
- 9 – Parinya Charoenphol (1981), Thai boxer, model and actress
- 9 – Bülent Ersoy (1952), Turkish singer and actress
- 9 – Roz Kaveney (1949), English transgender author
- 10 – Laerte (1951), Brazilian cartoonist and screenwriter
- 13 – Violet Chachki (1992), American genderqueer drag queen and musician
- 15 – Tash Sultana (1995), non-binary Australian singer-songwriter and musician
- 16 – Lou Sullivan (1951-1991), American transgender activist and author
- 19 – Erik Schinegger (1948), Austrian athlete
- 21 – Lana Wachowski (1965), American director, writer, producer
- 22 – Jennifer Finney Boylan (1958), American author
- 27 – Emma D'Arcy (1992), English non-binary actor
- 28 – Ataru Nakamura (1985), Japanese trans woman singer, songwriter, actress
- 30 – Elliot Fletcher (1996), American actor
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- 2 – Dee Palmer (1937), English musician
- 2 – Sylvia Rivera (1951–2002), American transgender rights activist
- 9 – Rebecca Sugar (1987), American non-binary director, animator, musician and screenwriter
- 10 – Angel Haze (1991), American rapper and singer
- 12 – Hailie Sahar (1988), American actress
- 13 – Carla Antonelli (1959), Canarian-Spanish actress and legislator
- 20 – Andreas Krieger (1966), German athlete
- 28 – Alexis Arquette (1969), American actress
- 3 - Nemo (1999), Swiss non-binary singer
- 9 – Sarah McBride (1990), American transgender rights activist, politician and author
- 11 – Quinn (1995), Canadian transgender non-binary soccer player and Olympic medallist
- 12 – Cara Delevingne (1992), English gender-fluid model, singer, and actress
- 12 – Bex Taylor-Klaus (1994), American non-binary actor
- 13 – Jin Xing (1967), Chinese dancer, choreographer and actress
- 14 – Arca (1989), Venezuelan singer, songwriter, producer
- 17 – Rachel Pollack (1945), American author
- 19 – Renée Richards (1934), American tennis player and ophthalmologist
- 20 – Demi Lovato (1992), American non-binary singer and performer
- 23 – Coccinelle (1931–2006), French actress, entertainer and singer
- 24 – Marsha P. Johnson (1945–1992), American transgender rights activist
- 27 – Kim Petras (1992), German singer songwriter
- 28 – Andreja Pejić (1991), Bosnian-Australian transgender model and actress
- 29 – Candis Cayne (1971), American actress
- 31 – Caroline Cossey (1954), British model
- 31 – Sara Ramirez (1975), Mexican-American non-binary actress and singer
- 1 – Leslie Feinberg (1949–2014), American transgender activist and author
- 5 – Ezra Furman (1986), American musician and singer
- 5 – Rose McGowan (1973), non-binary American actress, activist, model and author
- 11 – Deirdre McCloskey (1942), American academic
- 11 – Paul B. Preciado (1970), Spanish philosopher
- 13 – Ben Barres (1954–2017), American neurobiologist
- 13 – Philippa York (1958), Scottish cyclist and journalist
- 16 – Teddy Geiger (1988), American singer, songwriter and record producer
- 17 – Sophie (1986–2021), British record producer, songwriter, singer
- 23 – Sam Bettens (1972), Belgian musician and singer
- 26 – Jill Soloway (1965), non-binary American television creator, showrunner, director and writer
- 29 – Ester Martin Bergsmark (1982), Swedish director and screenwriter
- 30 – Ezra Miller (1992), American non-binary actor
- 1 – Isis King (1985), American transgender model and actress
- 2 – Jan Morris (1926–2020), Welsh author
- 5 – Chevalier d'Éon (1728–1810), French spy, diplomat and soldier
- 6 – Jazz Jennings (2000), American transgender television personality
- 14 – Arca (1989), Venezuelan musician
- 21 – Natalie Wynn (1988), American transgender Youtuber
- 23 – Amandla Stenberg (1998), American non-binary actor and singer
- 24 – Anohni (1971), English singer and composer
- 25 – Claude Cahun (1894–1954), French photographer, sculptor and writer
- 25 – Miss Major Griffin-Gracy (1940), American transgender rights activist
- 26 – Holly Woodlawn (1946–2015), Puerto Rican transgender actress
- 28 – Caitlyn Jenner (1949), American television personality and Olympic gold medal–winning decathlete.
- 8 – Laura Jane Grace (1980), American singer, songwriter and guitarist
- 14 – Wendy Carlos (1939), American musician and composer
- 15 – Leelah Alcorn (1997-2014), American transgender girl
- 21 – Amanda Lepore (1967), American model, singer and performance artist
- 23 – Miley Cyrus (1992), American gender fluid singer, songwriter, and actress
- 24 – Candy Darling (1944-1974), American actress and transsexual icon
- 29 – Fallon Fox (1975), American transgender mixed martial artist
- 29 – Liv Hewson (1995), Australian non-binary actor
- 1 – Janelle Monae (1985), American non-binary singer, actress and author
- 4 – Mina Caputo (1973), American singer
- 12 – Brandon Teena (1972–1993), American trans man murder victim
- 17 – Chelsea Manning (1987), American activist and whistleblower
- 19 – King Princess (1998), American genderqueer singer-songwriter
- 20 – Bell Nuntita (1983), Thai actress, singer
- 22 – Sandra Forgues (1969), French canoeist, olympic medalist, transgender woman
- 25 – Mianne Bagger (1966), Danish golfer
- 28 – Lili Elbe (1882–1931), Danish transgender artist
- 28 – Lilly Wachowski (1967), American director, writer, producer
- 29 – Billy Tipton (1914–1989), American musician and bandleader
- 31 – Diana Sacayán (1975–2015), Argentinian transgender rights activist
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