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Ferugliotheriidae is one of two known families in the order Gondwanatheria, an enigmatic group of extinct mammals. Gondwanatheres have been classified as a group of uncertain affinities or as members of Multituberculata, a major extinct mammalian order. The best-known representative of Ferugliotheriidae is the genus Ferugliotherium from the Late Cretaceous epoch in Argentina. A second genus, Trapalcotherium, is known from a single tooth, a first lower molariform (molar-like tooth), from a different Late Cretaceous Argentinean locality. Another genus known from a single tooth (in this case, a fourth lower premolar), Argentodites, was first described as an unrelated multituberculate, but later identified as possibly related to Ferugliotherium. Finally, a single tooth from the Paleogene of Peru, LACM 149371, perhaps a last upper molariform, may represent a related animal. Ferugliotheriids are known from isolated, low-crowned (brachydont) teeth and possibly a fragment of a lower jaw. Ferugliotherium is estimated to have weighed 70 g (2.5 oz).

Most ferugliotheriids come from the Late Cretaceous epoch (Campanian–Maastrichtian ages, 84–66 million years ago, or mya) of Argentina, where they may have lived in a marshy or seashore environment. They coexisted with mammals such as dryolestoids and a variety of other animals, including dinosaurs. Ferugliotheriids may have been herbivores or omnivores. (see more...)