Portal:History of science/Selected anniversaries/December 27
- 1571 - Birth of Johannes Kepler, German astronomer (d. 1630)
- 1654 - Birth of Jacob Bernoulli, Swiss mathematician (d. 1705)
- 1773 - Birth of George Cayley, English scientist, inventor, and politician (d. 1857)
- 1822 - Birth of Louis Pasteur, French scientist (d. 1895)
- 1831 - Charles Darwin embarks on his journey aboard the HMS Beagle, during which he will begin to formulate the theory of evolution
- 1845 - Ether anesthetic is used for childbirth for the first time by Dr. Crawford Williamson Long in Jefferson, Georgia
- 1900 - Death of William George Armstrong, English inventor, industrialist, and engineer (b. 1810)
- 1914 - Death of Charles Martin Hall, American chemist and inventor (b. 1863)
- 1938 - Death of Calvin Bridges, American geneticist (b. 1889)
- 1974 - Death of Vladimir Aleksandrovich Fock, Russian physicist (b. 1898)