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Sagara Sanosuke (相楽 左之助) is a fictional character from the Rurouni Kenshin anime and manga series created by Nobuhiro Watsuki. He is known as Sanosuke Sagara in the English adaptation of the anime and is nicknamed Sano. Watsuki, being a fan of the Shinsengumi, created Sanosuke by basing his name and characteristics on that of a real Shinsengumi member named Harada Sanosuke.

Set during a fictional version of Japan in the pre-Meiji period, Sanosuke is a former member of the Sekihō Army. When the group is destroyed by the Meiji Government, he becomes a fighter-for-hire to calm his anger by fighting. During his introduction in the series, he encounters the wanderer Himura Kenshin, who easily defeats him and is able to convince him to stop his mercenary work and instead start protecting people. After that encounter, Sanosuke becomes Kenshin's best friend as well as his partner in most of their fights. He has also appears in the featured film of the series and in other media relating to the Rurouni Kenshin franchise, including a plethora of electronic games and original video animations (OVAs).