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Orochimaru (大蛇丸) is a fictional character from Naruto, a manga series created by Masashi Kishimoto. Orochimaru is a former ninja from the village of Konohagakure who is well known for work in wars which earned him the title of Sannin and becomes a terrorist as a means to cheat death, and built his own ninja village Otogakure. He succeeds to some extent in obtaining immortality by transferring between different host bodies, which became one of his driving motivations throughout the series as he targets Sasuke Uchiha for his genetic heritage. By the events of Boruto: Naruto Next Generations, he has seemingly redeemed himself and has sent his experiment Mitsuki to Konoha to become a ninja. Orochimaru has appeared in media outside the Naruto anime and manga, including several video games.

Based on Japanese mythology, Orochimaru was created as one of the series' main antagonists, and was intended to represent the opposite of the protagonists' morals and values.