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Piet Gros

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Piet Gros
Piet Gros (2010)
Born (1962-07-31) July 31, 1962 (age 62)
Dokkum, The Netherlands
NationalityDutch
OccupationProfessor of Biomacromolecular Crystallography
EmployerUtrecht University
Known forProtein crystallography, complement system
Awards2010 Spinoza Prize

Piet Gros (born July 31, 1962 in Dokkum) is a Dutch chemist and professor biomacromolecular crystallography at Utrecht University. In 2010 he received the NWO Spinoza Prize for the elucidation of the three-dimensional structure of the C3 protein, which plays a central role in the complement system and contributes to innate immunity.

Biography

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Gros was born in Dokkum, Netherlands. He studied chemistry at the University of Groningen, where he graduated cum laude with a master's degree. Five years later Gros received his PhD degree cum laude at the same university, with a thesis on protein crystallography. Subsequently he became a postdoctoral researcher at the ETH Zurich and later at Yale University. In 1994 Gros was given a position at Utrecht University to conduct experimental research towards new applications for protein crystallography. In 2002 he was given the position of full professor. From 2007 until 2010 Gros was head of the department of chemistry and from 2012 to 2016 he was scientific director of the Bijvoet Centre for Biomolecular Research.[1] Gros received an ERC Advanced grant of the European Research Council in 2008,[2] is a member of the Royal Netherlands Academy of Arts and Sciences (KNAW) since 2010[3] and in April 2013, Gros became Knight in the Order of the Netherlands Lion, when he received a Royal Decoration for his scientific achievements.[4][5]

Research

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The main expertise of Gros is in the area of protein crystallography methodology and its application to large human plasma proteins and cell-surface receptors and membrane proteins.[6] Among his findings are the molecular mechanisms that underlie key steps in the human immune defense by the complement system, such as the mode of action of complement component 3[7] and component 8.[8] Other research in his lab has focussed on the adhesion of von Willebrand factor (A1 domain) to its platelet receptor GpIb and the structures of pathogenic bacterial outer-membrane proteins[6] and the movement of individual atoms within the defined protein structures.[9]

Honours and awards

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In 2010, Gros received the NWO Spinoza Prize for the elucidation of the three-dimensional structure of the C3 protein. This protein is part of the oldest part of the immune system that is present in the human body, the complement system. Using structural biology techniques such as protein crystallography, the research group of Gros studies structures and chemical interactions that are at the basis of immunological processes such as the complement system.[10][11][12] He is the recipient of the 2018 Gregori Aminoff Prize, an international prize awarded since 1979 by the Royal Swedish Academy of Sciences in the field of crystallography.[13] In 2024, he was awarded the ICS Legacy Award of the International Complement Society [14] and the Bijvoet Medal of the Bijvoet Centre for Biomolecular Research.[15]

References

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  1. ^ Anko de Jong (June 12, 2010). "Pionier in eiwit: Interview met Piet Gros". Leeuwarder Courant (in Dutch).
  2. ^ "Utrechtse hoogleraren Piet Gros en Marco van Leeuwen krijgen ERC Advanced Grant". www.uu.nl (in Dutch). November 17, 2008.
  3. ^ "Piet Gros". Royal Netherlands Academy of Arts and Sciences. Archived from the original on February 24, 2020.
  4. ^ "Zeven Koninklijke onderscheidingen aan de Universiteit Utrecht". www.uu.nl (in Dutch). April 26, 2013.
  5. ^ Xander Bronkhorst (April 26, 2013). "Lintjesregen in Academiegebouw" (in Dutch). DUB.
  6. ^ a b "prof. dr. P. (Piet) Gros". www.uu.nl. Retrieved May 1, 2013.
  7. ^ Forneris, F.; Ricklin, D.; Wu, J.; Tzekou, A.; Wallace, R. S.; Lambris, J. D.; Gros, P. (2010). "Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation". Science. 330 (6012): 1816–20. Bibcode:2010Sci...330.1816F. doi:10.1126/science.1195821. PMC 3087196. PMID 21205667.
  8. ^ Hadders, M. A.; Beringer, D. X.; Gros, P. (2007). "Structure of C8 -MACPF Reveals Mechanism of Membrane Attack in Complement Immune Defense". Science. 317 (5844): 1552–4. doi:10.1126/science.1147103. hdl:1874/26831. PMID 17872444. S2CID 44959101.
  9. ^ "Beweging moleculen in beeld". ScienceGuide (in Dutch). 2012-12-21. Retrieved May 1, 2013.
  10. ^ "Spinozawinnaars 2010". NWO. June 7, 2010. Archived from the original on October 29, 2012.
  11. ^ "Winnaar Spinozapremie 2010: Piet Gros, biomacromoleculair kristallograaf". Volkskrant (in Dutch). June 7, 2010.
  12. ^ "NWO Spinoza Prize for Psychologist, Astronomer, Chemist And Classicist". www.sciencenewsline.com. June 7, 2010. Archived from the original on June 15, 2013. Retrieved May 1, 2013.
  13. ^ "This year's crystallography prize awarded to a world-leading protein researcher". September 15, 2017. Retrieved 2017-09-19.
  14. ^ "2024 Legacy Awardee - Piet Gros". March 14, 2024. Retrieved 2024-05-07.
  15. ^ "Bijvoet Medal awarded to Piet Gros". May 6, 2024. Retrieved 2024-05-07.
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