Phosphoribosyl-AMP cyclohydrolase
phosphoribosyl-AMP cyclohydrolase | |||||||||
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Identifiers | |||||||||
EC no. | 3.5.4.19 | ||||||||
CAS no. | 37289-22-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) is an enzyme that catalyzes the chemical reaction
- 1-(5-phosphoribosyl)-AMP + H2O 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4-carboxamide
Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-AMP and H2O, whereas its two products are [[1-(5-phosphoribosyl)-5-[(5-]] and [[phosphoribosylamino)methylideneamino]imidazole-4-carboxamide]].
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase. Other names in common use include PRAMP-cyclohydrolase, and phosphoribosyladenosine monophosphate cyclohydrolase. This enzyme participates in histidine metabolism.
Structural studies
[edit]As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1ZPS.
References
[edit]- Minson AC, Creaser EH (1969). "Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa". Biochem. J. 114 (1): 49–56. doi:10.1042/bj1140049. PMC 1184794. PMID 4309307.