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Phenylacetaldehyde dehydrogenase

From Wikipedia, the free encyclopedia
phenylacetaldehyde dehydrogenase
Identifiers
EC no.1.2.1.39
CAS no.58943-37-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a phenylacetaldehyde dehydrogenase (EC 1.2.1.39) is an enzyme that catalyzes the chemical reaction

phenylacetaldehyde + NAD+ + H2O phenylacetate + NADH + 2 H+

The 3 substrates of this enzyme are phenylacetaldehyde, NAD+, and H2O, whereas its 3 products are phenylacetate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phenylacetaldehyde:NAD+ oxidoreductase. This enzyme participates in phenylalanine metabolism and styrene degradation.

References

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  • Fujioka M, Morino Y, Wada H (1970). Metabolism of phenylalanine (Achromobacter eurydice). III Phenylacetaldehyde dehydrogenase. Methods Enzymol. Vol. 17A. pp. 593–596. doi:10.1016/0076-6879(71)17245-x.