Phenicarbazide
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| Other names | 1-Phenylsemicarbazide; Kryogenin |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.002.794 |
| Chemical and physical data | |
| Formula | C7H9N3O |
| Molar mass | 151.169 g·mol−1 |
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Phenicarbazide is a semicarbazide and an antipyretic substance. It is carcinogenic in mice.[1]
Preparation
[edit]Phenicarbazide can be obtained by mixing phenylhydrazine with acetic acid in aqueous solution with the addition of potassium cyanide. It is also obtained from the reaction of phenylhydrazine with urea.[2]
Properties
[edit]Phenicarbazide is a flammable, hard to ignite, crystalline, beige solid that is practically insoluble in water. It decomposes on heating.[3]
Uses
[edit]Phenicarbazide is an intermediate in the syntheses of a series of chemical compounds by cyclocondensation reactions.[4] It was investigated as an analgesic and antipyretic in the 1970s and was used in combination preparations.
References
[edit]- ^ "Phenicarbazide". International Agency for Research on Cancer (IARC) - Summaries & Evaluations. 25 March 1998.
- ^ Bruchhausen F, Ebel S, Hackenthal E, Holzgrabe U, Albinus M, Amschler G, Angerer E (1999). Hagers Handbuch der Pharmazeutischen Praxis : Stoffe L-Z Folgeband 5 (5. vollständig neubearbeitete Auflage ed.). Berlin, Heidelberg. p. 420. ISBN 978-3-642-58388-9. OCLC 913646782.
{{cite book}}: CS1 maint: location missing publisher (link) - ^ "Phenicarbazid". GESTIS-Stoffdatenbank. Retrieved 2022-10-18.
- ^ "1-Phenylsemicarbazide". Sigma-Aldrich.
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