Permissiveness (biology)

In endocrinology, permissiveness is a biochemical phenomenon in which the presence of one hormone is required in order for another hormone to exert its full effects on a target cell. Hormones can interact in permissive, synergistic, or antagonistic ways. The chemical classes of hormones include amines, polypeptides, glycoproteins and steroids. Permissive hormones act as precursors to active hormones and may be classified as either prohormones or prehormones. It stimulate the formation of receptors of that hormone.

Examples

Thyroid hormone increases the number of beta-adrenergic receptors available for epinephrine at the latter's target cell, thereby increasing epinephrine's effect on that cell. Specially in cardiac cell. Without the thyroid hormone, epinephrine would have only a weak effect.^[1]

Cortisol is required for the response of vascular and bronchial smooth muscle to catecholamines.^[2] Cortisol is also required for the lipolytic effect of catecholamines, ACTH, and growth hormone on fat cells.^[2] Cortisol is also required for the calorigenic effects of glucagon and catecholamines.^[3]

The effects of a hormone in the body depend on its concentration. Permissive actions of glucocorticoids like cortisol generally occur at low concentrations. Abnormally high amounts of a hormone can result in atypical effects. Glucocorticoids function by attaching to cytoplasmic receptors to either enhance or suppress changes in the transcription of DNA and thus the synthesis of proteins. Glucocorticoids also inhibit the secretion of cytokines via post-translational modification effects.^[4]

References

^ Sherwood, Lauralee (2007). "Ch18". In Peter Adams (ed.). Human physiology from cells to systems (6th ed.). Thomson Brooks/Cole. ISBN 978-0-495-01485-0.
^ ^a ^b Katzung, Bertram G., ed. (2018). Basic & Clinical Pharmacology. A Lange medical book (14th ed.). New York Chicago San Francisco Athens London Madrid Mexico City Milan New Delhi Singapore Sydney Toronto: McGraw-Hill Education. p. 707. ISBN 978-1-259-64115-2.
^ Barrett, Kim (January 29, 2019). Ganong's Review of Medical Physiology (26th ed.). McGraw Hill. p. 341. ISBN 978-1260122404.
^ Stoelting, R., & Shafer, S. (2015). Stoelting's handbook of pharmacology and physiology in anesthetic practice. (3rd ed.).

This biochemistry article is a stub. You can help Wikipedia by expanding it.

[1] Sherwood, Lauralee (2007). "Ch18". In Peter Adams (ed.). Human physiology from cells to systems (6th ed.). Thomson Brooks/Cole. ISBN 978-0-495-01485-0.

[:0-2] Katzung, Bertram G., ed. (2018). Basic & Clinical Pharmacology. A Lange medical book (14th ed.). New York Chicago San Francisco Athens London Madrid Mexico City Milan New Delhi Singapore Sydney Toronto: McGraw-Hill Education. p. 707. ISBN 978-1-259-64115-2.

[3] Barrett, Kim (January 29, 2019). Ganong's Review of Medical Physiology (26th ed.). McGraw Hill. p. 341. ISBN 978-1260122404.

[4] Stoelting, R., & Shafer, S. (2015). Stoelting's handbook of pharmacology and physiology in anesthetic practice. (3rd ed.).

[1]

[2]

[3]

[4]