Pantoate 4-dehydrogenase
| pantoate 4-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.106 | ||||||||
| CAS no. | 37250-38-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a pantoate 4-dehydrogenase (EC 1.1.1.106) is an enzyme that catalyzes the chemical reaction
- (R)-pantoate + NAD+ (R)-4-dehydropantoate + NADH + H+
Thus, the two substrates of this enzyme are (R)-pantoate and NAD+, whereas its 3 products are (R)-4-dehydropantoate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NAD+ 4-oxidoreductase. Other names in common use include pantoate dehydrogenase, pantothenase, and D-pantoate:NAD+ 4-oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.
References
[edit]- Goodhue CT, Snell EE (1966). "The bacterial degradation of pantothenic acid. 3. Enzymatic formation of aldopantoic acid". Biochemistry. 5 (2): 403–8. doi:10.1021/bi00866a003. PMID 4287370.
