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PURB

From Wikipedia, the free encyclopedia
PURB
Identifiers
AliasesPURB, PURBETA, purine-rich element binding protein B, purine rich element binding protein B
External IDsOMIM: 608887; MGI: 1338779; HomoloGene: 69087; GeneCards: PURB; OMA:PURB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033224

NM_011221

RefSeq (protein)

NP_150093

NP_035351

Location (UCSC)Chr 7: 44.88 – 44.89 MbChr 11: 6.42 – 6.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.[5][6]

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans.

Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146676Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000094483Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bergemann AD, Ma ZW, Johnson EM (Dec 1992). "Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein". Mol Cell Biol. 12 (12): 5673–82. doi:10.1128/mcb.12.12.5673. PMC 360507. PMID 1448097.
  6. ^ a b "Entrez Gene: PURB purine-rich element binding protein B".

Further reading

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