PRSS3

PRSS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H4W, 2R9P, 3L33, 3L3T, 3P92, 3P95, 4DG4, 4U30, 4U32, 5C67
Identifiers
Aliases	PRSS3, MTG, PRSS4, T9, TRY3, TRY4, protease, serine 3, serine protease 3
External IDs	OMIM: 613578; MGI: 102757; HomoloGene: 106639; GeneCards: PRSS3; OMA:PRSS3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.3 Start 33,750,679 bp End 33,799,231 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B1 Start 41,279,203 bp End 41,282,466 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas mucosa of ileum mucosa of transverse colon jejunal mucosa duodenum mucosa of sigmoid colon islet of Langerhans rectum beta cell gums Top expressed in pancreas islet of Langerhans stomach embryo colon quadriceps femoris muscle duodenum esophagus jejunum primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding peptidase activity serine-type endopeptidase activity protein binding hydrolase activity metal ion binding serine-type peptidase activity Cellular component extracellular region extracellular space tertiary granule lumen Biological process digestion cobalamin metabolic process zymogen activation endothelial cell migration proteolysis antimicrobial humoral response neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5646 22074 Ensembl ENSG00000010438 ENSMUSG00000054106 UniProt P35030 Q9R0T7 RefSeq (mRNA) NM_001197097 NM_001197098 NM_002771 NM_007343 NM_011646 RefSeq (protein) NP_001184026 NP_001184027 NP_002762 NP_031369 NP_035776 Location (UCSC) Chr 9: 33.75 – 33.8 Mb Chr 6: 41.28 – 41.28 Mb PubMed search
Wikidata
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Protease, serine, 3 is a protein that in humans is encoded by the PRSS3 gene.

Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.

Further reading

• Koistinen H, Koistinen R, Zhang WM, Valmu L, Stenman UH (April 2009). "Nexin-1 inhibits the activity of human brain trypsin". Neuroscience. 160 (1): 97–102. doi:10.1016/j.neuroscience.2009.02.042. PMID 19249338. S2CID 23924027.
• Tani T, Kawashima I, Mita K, Takiguchi Y (March 1990). "Nucleotide sequence of the human pancreatic trypsinogen III cDNA". Nucleic Acids Research. 18 (6): 1631. doi:10.1093/nar/18.6.1631. PMC 330537. PMID 2326201.
• Hayashi H, Kohno T, Yasui K, Murota H, Kimura T, Duncan GS, Nakashima T, Yamamoto K, Katayama I, Ma Y, Chua KJ, Suematsu T, Shimokawa I, Akira S, Kubo Y, Mak TW, Matsuyama T (November 2011). "Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription". Proceedings of the National Academy of Sciences of the United States of America. 108 (46): 18766–71. Bibcode:2011PNAS..10818766H. doi:10.1073/pnas.1116273108. PMC 3219097. PMID 22042864.
• Salameh MA, Robinson JL, Navaneetham D, Sinha D, Madden BJ, Walsh PN, Radisky ES (January 2010). "The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin". The Journal of Biological Chemistry. 285 (3): 1939–49. doi:10.1074/jbc.M109.057216. PMC 2804352. PMID 19920152.
• Masson E, Le Maréchal C, Chen JM, Férec C (August 2008). "Absence of mesotrypsinogen gene (PRSS3) copy number variations in patients with chronic pancreatitis". Pancreas. 37 (2): 227–8. doi:10.1097/MPA.0b013e3181654b6a. PMID 18665091.
• Nyaruhucha CN, Kito M, Fukuoka SI (April 1997). "Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance". The Journal of Biological Chemistry. 272 (16): 10573–8. doi:10.1074/jbc.272.16.10573. PMID 9099703.
• Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW (September 2007). "Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia". The Journal of Biological Chemistry. 282 (36): 26089–100. doi:10.1074/jbc.M703840200. PMID 17623652.
• Huntington JA, Read RJ, Carrell RW (October 2000). "Structure of a serpin-protease complex shows inhibition by deformation". Nature. 407 (6806): 923–6. Bibcode:2000Natur.407..923H. doi:10.1038/35038119. PMID 11057674. S2CID 205009937.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.