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PRSS16

From Wikipedia, the free encyclopedia
PRSS16
Identifiers
AliasesPRSS16, TSSP, protease, serine 16, serine protease 16
External IDsOMIM: 607169; MGI: 1859181; HomoloGene: 38106; GeneCards: PRSS16; OMA:PRSS16 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005865

NM_019429

RefSeq (protein)

NP_005856

NP_062302

Location (UCSC)Chr 6: 27.25 – 27.26 MbChr 13: 22.19 – 22.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thymus-specific serine protease is an enzyme that in humans is encoded by the PRSS16 gene.[5][6]

This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells.

The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112812Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006179Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bowlus CL, Ahn J, Chu T, Gruen JR (Nov 1999). "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus". Cellular Immunology. 196 (2): 80–6. doi:10.1006/cimm.1999.1543. PMID 10527559.
  6. ^ a b "Entrez Gene: PRSS16 protease, serine, 16 (thymus)".

Further reading

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