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PRMT7

From Wikipedia, the free encyclopedia

Protein arginine methyltransferase 7 (PRMT7) is a protein that in humans is encoded by the PRMT7 gene.[1] Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PRMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing.[1][2]

PRMT7 was initially identified as a Type II protein lysine methyltransferase, indicating its role in the symmetric dimethylation of arginine residues. However, it was later reclassified as a Type III protein lysine methyltransferase, meaning it facilitates the mono-methylation of arginine residues. As of 2023, PRMT7 remains the sole member of the Type III PRMT category.[3]

References

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  1. ^ a b "Protein arginine methyltransferase 7". Retrieved 2011-12-06.
  2. ^ Miranda, T. B.; Miranda, M.; Frankel, A.; Clarke, S. (2004). "PRMT7 is a Member of the Protein Arginine Methyltransferase Family with a Distinct Substrate Specificity". Journal of Biological Chemistry. 279 (22): 22902–22907. doi:10.1074/jbc.M312904200. PMID 15044439.
  3. ^ Tollefsbol, Trygve O., ed. (2023). Handbook of epigenetics: the new molecular and medical genetics (Third ed.). London, United Kingdom; San Diego, CA: Academic Press, an imprint of Elseiver. p. 36. ISBN 978-0-323-91909-8.

Further reading

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