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Protein-coding gene in the species Homo sapiens
Protamine 2 is a protein that in humans is encoded by the PRM2 gene .[ 5]
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis , and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus.
Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides . Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015].
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
