Jump to content

PRDX6

From Wikipedia, the free encyclopedia
(Redirected from PRDX6 (gene))

PRDX6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRDX6, 1-Cys, AOP2, HEL-S-128m, NSGPx, PRX, aiPLA2, p29, peroxiredoxin 6, LPCAT-5
External IDsOMIM: 602316; MGI: 894320; HomoloGene: 3606; GeneCards: PRDX6; OMA:PRDX6 - orthologs
EC number1.11.1.9
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004905

NM_001303408
NM_007453

RefSeq (protein)

NP_004896

NP_001290337
NP_031479

Location (UCSC)Chr 1: 173.48 – 173.49 MbChr 1: 161.07 – 161.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene.[5][6] It is a member of the peroxiredoxin family of antioxidant enzymes. Peroxiredoxin 6 is widely distributed in several organs, especially the lungs.[7]

Function

[edit]

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117592Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026701Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Phelan SA (Mar 2001). "AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant". Antioxidants & Redox Signaling. 1 (4): 571–584. doi:10.1089/ars.1999.1.4-571. PMID 11233154.
  6. ^ a b "Entrez Gene: PRDX6 peroxiredoxin 6".
  7. ^ Jia W, Dong C, Li B (January 2023). "Anti-Oxidant and Pro-Oxidant Effects of Peroxiredoxin 6: A Potential Target in Respiratory Diseases". Cells. 12 (1): 181. doi:10.3390/cells12010181. ISSN 2073-4409. PMC 9818991. PMID 36611974.

Further reading

[edit]