PPP6C

PPP6C
Identifiers
Aliases	PPP6C, PP6, PP6C, protein phosphatase 6 catalytic subunit
External IDs	OMIM: 612725; MGI: 1915107; HomoloGene: 68273; GeneCards: PPP6C; OMA:PPP6C - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	125,189,939 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	39,116,463 bp
RNA expression pattern
	Top expressed in
	oocyte; ; sperm; ; secondary oocyte; ; gingival epithelium; ; parotid gland; ; buccal mucosa cell; ; palpebral conjunctiva; ; amniotic fluid; ; deltoid muscle; ; epithelium of nasopharynx;
	Top expressed in
	medullary collecting duct; ; tail of embryo; ; genital tubercle; ; renal corpuscle; ; triceps brachii muscle; ; endocardial cushion; ; vastus lateralis muscle; ; spermatid; ; temporal muscle; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphoprotein phosphatase activity; hydrolase activity; metal ion binding; protein serine/threonine phosphatase activity;
Cellular component	cytoplasm; cytosol; Golgi membrane; mitochondrion;
Biological process	cell cycle; COPII vesicle coating; protein dephosphorylation; immune system process; innate immune response; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5537
	67857
	ENSG00000119414
	ENSMUSG00000026753
	O00743
	Q9CQR6
	NM_001123355; NM_001123369; NM_002721
	NM_024209
	NP_001116827; NP_001116841; NP_002712
	NP_077171
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 6 catalytic subunit is an enzyme that in humans is encoded by the PPP6C gene.^[5]^[6]

Interactions

PPP6C has been shown to interact with IGBP1.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119414 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026753 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bastians H, Krebber H, Vetrie D, Hoheisel J, Lichter P, Ponstingl H, Joos S (April 1997). "Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3". Genomics. 41 (2): 296–7. doi:10.1006/geno.1997.4640. PMID 9143513.
^ "Entrez Gene: PPP6C protein phosphatase 6, catalytic subunit".
^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, et al. (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
^ Chen J, Peterson RT, Schreiber SL (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.

Bastians H, Ponstingl H (December 1996). "The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation". Journal of Cell Science. 109 ( Pt 12) (Pt 12): 2865–74. doi:10.1242/jcs.109.12.2865. PMID 9013334.
Chen J, Peterson RT, Schreiber SL (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, et al. (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Nasu-Nishimura Y, Hayashi T, Ohishi T, Okabe T, Ohwada S, Hasegawa Y, et al. (June 2006). "Role of the Rho GTPase-activating protein RICS in neurite outgrowth". Genes to Cells. 11 (6): 607–14. doi:10.1111/j.1365-2443.2006.00966.x. PMID 16716191. S2CID 7935936.
Stefansson B, Brautigan DL (August 2006). "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon". The Journal of Biological Chemistry. 281 (32): 22624–34. doi:10.1074/jbc.M601772200. PMID 16769727.
Stefansson B, Brautigan DL (June 2007). "Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells". Cell Cycle. 6 (11): 1386–92. doi:10.4161/cc.6.11.4276. PMID 17568194.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119414 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026753 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9143513-5] Bastians H, Krebber H, Vetrie D, Hoheisel J, Lichter P, Ponstingl H, Joos S (April 1997). "Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3". Genomics. 41 (2): 296–7. doi:10.1006/geno.1997.4640. PMID 9143513.

[entrez-6] "Entrez Gene: PPP6C protein phosphatase 6, catalytic subunit".

[pmid16085932-7] Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, et al. (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

[pmid9647778-8] Chen J, Peterson RT, Schreiber SL (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.

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Interactions

References

Further reading