PPP4C

PPP4C
Identifiers
Aliases	PPP4C, PP4, PP4C, PPH3, PPP4, PPX, PP-X, protein phosphatase 4 catalytic subunit
External IDs	OMIM: 602035; MGI: 1891763; HomoloGene: 2038; GeneCards: PPP4C; OMA:PPP4C - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,085,376 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,391,668 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; stromal cell of endometrium; ; mucosa of transverse colon; ; right testis; ; left testis; ; skin of abdomen; ; skin of leg; ; ganglionic eminence; ; left adrenal gland;
	Top expressed in
	mandibular prominence; ; maxillary prominence; ; granulocyte; ; epiblast; ; somite; ; abdominal wall; ; primitive streak; ; thymus; ; ventricular zone; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; metal ion binding; NF-kappaB-inducing kinase activity; protein binding; hydrolase activity; protein serine/threonine phosphatase activity;
Cellular component	plasma membrane; nucleoplasm; microtubule organizing center; cytoskeleton; nucleus; protein phosphatase 4 complex; cytoplasm; cytosol;
Biological process	regulation of double-strand break repair via homologous recombination; NIK/NF-kappaB signaling; protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5531
	56420
	ENSG00000149923
	ENSMUSG00000030697
	P60510
	P97470
	NM_001303503; NM_001303504; NM_001303506; NM_001303507; NM_002720
	NM_019674; NM_001360464
	NP_001290432; NP_001290433; NP_001290435; NP_001290436; NP_002711
	NP_062648; NP_001347393
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.^[5]^[6]

Interactions

PPP4C has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149923 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030697 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S (May 1997). "Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization". Genomics. 42 (1): 181–2. doi:10.1006/geno.1997.4693. PMID 9177794.
^ "Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit".
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
^ ^a ^b ^c ^d Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
^ Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
^ Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.
^ Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y (Aug 2008). "Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6". FEBS Letters. 582 (19): 2843–9. doi:10.1016/j.febslet.2008.07.014. PMID 18634786. S2CID 27700566.

Brewis ND, Cohen PT (Dec 1992). "Protein phosphatase X has been highly conserved during mammalian evolution". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1171 (2): 231–3. doi:10.1016/0167-4781(92)90129-n. PMID 1336397.
Brewis ND, Street AJ, Prescott AR, Cohen PT (Mar 1993). "PPX, a novel protein serine/threonine phosphatase localized to centrosomes". The EMBO Journal. 12 (3): 987–96. doi:10.1002/j.1460-2075.1993.tb05739.x. PMC 413299. PMID 8384557.
Kloeker S, Bryant JC, Strack S, Colbran RJ, Wadzinski BE (Oct 1997). "Carboxymethylation of nuclear protein serine/threonine phosphatase X". The Biochemical Journal. 327 ( Pt 2) (Pt 2): 481–6. doi:10.1042/bj3270481. PMC 1218819. PMID 9359419.
Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.
Kloeker S, Wadzinski BE (Feb 1999). "Purification and identification of a novel subunit of protein serine/threonine phosphatase 4". The Journal of Biological Chemistry. 274 (9): 5339–47. doi:10.1074/jbc.274.9.5339. PMID 10026142.
Hastie CJ, Carnegie GK, Morrice N, Cohen PT (May 2000). "A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres". The Biochemical Journal. 347 Pt 3 (Pt 3): 845–55. doi:10.1042/0264-6021:3470845. PMC 1221024. PMID 10769191.
Yeh PY, Yeh KH, Chuang SE, Song YC, Cheng AL (Jun 2004). "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation". The Journal of Biological Chemistry. 279 (25): 26143–8. doi:10.1074/jbc.M402362200. PMID 15073167.
Mihindukulasuriya KA, Zhou G, Qin J, Tan TH (Nov 2004). "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation". The Journal of Biological Chemistry. 279 (45): 46588–94. doi:10.1074/jbc.M408067200. PMID 15331607.
Zhou G, Boomer JS, Tan TH (Nov 2004). "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1". The Journal of Biological Chemistry. 279 (47): 49551–61. doi:10.1074/jbc.M410317200. PMID 15364934.
Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E (Apr 2005). "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4". Genes & Development. 19 (7): 827–39. doi:10.1101/gad.1286005. PMC 1074320. PMID 15805470.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149923 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030697 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9177794-5] Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S (May 1997). "Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization". Genomics. 42 (1): 181–2. doi:10.1006/geno.1997.4693. PMID 9177794.

[entrez-6] "Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit".

[pmid18715871-7] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

[pmid17353931-8] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid16085932-9] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

[pmid9647778-10] Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.

[pmid9837938-11] Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.

[pmid18634786-12] Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y (Aug 2008). "Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6". FEBS Letters. 582 (19): 2843–9. doi:10.1016/j.febslet.2008.07.014. PMID 18634786. S2CID 27700566.

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Interactions

References

Further reading