PPM1K

PPM1K
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IQ1, 4DA1
Identifiers
Aliases	PPM1K, BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07, protein phosphatase, Mg2+/Mn2+ dependent 1K
External IDs	OMIM: 611065; MGI: 2442111; HomoloGene: 36819; GeneCards: PPM1K; OMA:PPM1K - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	88,284,769 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	57,535,468 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; right ventricle; ; postcentral gyrus; ; middle temporal gyrus; ; internal globus pallidus; ; superior frontal gyrus; ; palpebral conjunctiva; ; pars compacta; ; pars reticulata;
	Top expressed in
	piriform cortex; ; interventricular septum; ; medial geniculate nucleus; ; left lobe of liver; ; Region I of hippocampus proper; ; globus pallidus; ; myocardium of ventricle; ; inferior colliculi; ; lateral geniculate nucleus; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine phosphatase activity; protein binding; catalytic activity; phosphoprotein phosphatase activity; hydrolase activity; metal ion binding; cation binding;
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	protein dephosphorylation; branched-chain amino acid catabolic process; positive regulation of pyruvate dehydrogenase activity;
	Sources:Amigo / QuickGO
Orthologs
	152926
	243382
	ENSG00000163644
	ENSMUSG00000037826
	Q8N3J5
	Q8BXN7
	NM_152542
	NM_175523
	NP_689755
	NP_780732
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1K, mitochondrial is an enzyme that in humans is encoded by the PPM1K gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163644 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037826 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: PPM1K protein phosphatase 1K (PP2C domain containing)".

Lu G, Ren S, Korge P, et al. (2007). "A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development". Genes Dev. 21 (7): 784–96. doi:10.1101/gad.1499107. PMC 1838530. PMID 17374715.
Joshi M, Jeoung NH, Popov KM, Harris RA (2007). "Identification of a novel PP2C-type mitochondrial phosphatase". Biochem. Biophys. Res. Commun. 356 (1): 38–44. doi:10.1016/j.bbrc.2007.02.108. PMC 1876681. PMID 17336929.
Dai J, Zhang J, Sun Y, et al. (2006). "Characterization of a novel human protein phosphatase 2C family member, PP2Ckappa". Int. J. Mol. Med. 17 (6): 1117–23. doi:10.3892/ijmm.17.6.1117. PMID 16685424.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163644 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037826 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: PPM1K protein phosphatase 1K (PP2C domain containing)".

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References

Further reading