POP4 (gene)

POP4
Identifiers
Aliases	POP4, RPP29, POP4 homolog, ribonuclease P/MRP subunit
External IDs	OMIM: 606114; MGI: 1913411; HomoloGene: 31392; GeneCards: POP4; OMA:POP4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	29,617,237 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	37,970,847 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; granulocyte; ; right coronary artery; ; left adrenal cortex; ; mucosa of transverse colon; ; buccal mucosa cell; ; left coronary artery; ; olfactory zone of nasal mucosa;
	Top expressed in
	ganglionic eminence; ; blastocyst; ; ventricular zone; ; maxillary prominence; ; mandibular prominence; ; medial ganglionic eminence; ; morula; ; dermis; ; endothelial cell of lymphatic vessel; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ribonuclease activity; protein binding; ribonuclease P RNA binding; ribonuclease MRP activity; hydrolase activity; RNA binding; ribonuclease P activity;
Cellular component	ribonuclease P complex; nucleolus; nucleus; nucleoplasm; multimeric ribonuclease P complex; ribonuclease MRP complex;
Biological process	tRNA processing; RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA 5'-leader removal; rRNA processing; RNA processing; RNA phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	10775
	66161
	ENSG00000105171
	ENSMUSG00000030423
	O95707
	Q9CR08
	NM_006627
	NM_025390
	NP_006618
	NP_079666
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonuclease P protein subunit p29 is an enzyme that in humans is encoded by the POP4 gene.^[5]^[6]^[7]

Interactions

POP4 has been shown to interact with RPP38^[8] and POP1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105171 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030423 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ van Eenennaam H, Pruijn GJ, van Venrooij WJ (Jul 1999). "hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes". Nucleic Acids Res. 27 (12): 2465–72. doi:10.1093/nar/27.12.2465. PMC 148449. PMID 10352175.
^ Jarrous N, Eder PS, Wesolowski D, Altman S (Mar 1999). "Rpp14 and Rpp29, two protein subunits of human ribonuclease P". RNA. 5 (2): 153–7. doi:10.1017/S135583829800185X. PMC 1369747. PMID 10024167.
^ "Entrez Gene: POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)".
^ ^a ^b Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.
Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P". RNA. 7 (7): 937–41. doi:10.1017/S1355838201010299. PMC 1370153. PMID 11455963.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105171 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030423 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10352175-5] van Eenennaam H, Pruijn GJ, van Venrooij WJ (Jul 1999). "hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes". Nucleic Acids Res. 27 (12): 2465–72. doi:10.1093/nar/27.12.2465. PMC 148449. PMID 10352175.

[pmid10024167-6] Jarrous N, Eder PS, Wesolowski D, Altman S (Mar 1999). "Rpp14 and Rpp29, two protein subunits of human ribonuclease P". RNA. 5 (2): 153–7. doi:10.1017/S135583829800185X. PMC 1369747. PMID 10024167.

[entrez-7] "Entrez Gene: POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)".

[pmid15096576-8] Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.

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Interactions

References

Further reading